435337-97-6

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 98-86-2 acetophenone 
• 4815-36-5 ethyl 2-amino-4-phenyl-thiophene-3-carboxylate 
• 1122-82-3 isothiocyanatocyclohexane 

Downstream Products

• 851852-86-3 3-cyclohexyl-2-mercapto-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one 
• 851853-18-4 (3-cyclohexyl-4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylsulfanyl)acetic acid ethyl ester 

Relevant academic research and scientific papers

2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation

The cysteine protease falcipain-2 (FP-2) of Plasmodium falciparum is a principal cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites, making it become an attractive target enzyme for developing anti-malarial drugs.

Structure-activity relationship study of novel tissue transglutaminase inhibitors

Thieno[2,3-d]pyrimidin-4-one acylhydrazide derivatives were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative