436864-62-9

Usage

Uses

Used in Scientific Research:
3-(4-Aminonaphthalen-1-yl)-N-BOC-L-alanine is used as a research compound for studying its chemical properties and potential applications in various fields. Its unique structure and the presence of the Boc group make it an interesting subject for exploration in the realm of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(4-Aminonaphthalen-1-yl)-N-BOC-L-alanine is used as a building block in the synthesis of complex molecules and drug candidates. Its incorporation into drug molecules can potentially enhance their therapeutic properties, such as improving their stability, solubility, or bioavailability.
Used in Drug Development:
3-(4-Aminonaphthalen-1-yl)-N-BOC-L-alanine is used as a key intermediate in the development of new drugs. Its presence in a drug molecule can contribute to the overall efficacy and safety profile of the final product, making it a valuable component in the drug discovery process.
Used in Laboratory Research:
3-(4-Aminonaphthalen-1-yl)-N-BOC-L-alanine is used as a reagent in laboratory experiments, where it can be employed to study the interactions between different chemical entities or to test the effects of modifications to its structure on the properties of the resulting compounds.

InChI:InChI=1/C18H22N2O4/c1-18(2,3)24-17(23)20-15(16(21)22)10-11-8-9-14(19)13-7-5-4-6-12(11)13/h4-9,15H,10,19H2,1-3H3,(H,20,23)(H,21,22)/t15-/m0/s1

Upstream product

• 436864-61-8 S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid methyl ester 
• 2298-07-9 4-Bromo-1-naphthylamine 
• 93267-04-0 N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester 

Downstream Products

• 521274-10-2 3-[5-(2-tert-butoxycarbonylamino-3-{4-[(2-carboxy-phenyl)-hydroxyoxalyl-amino]-naphthalen-1-yl}-propionylamino)-pentyloxy]-naphthalene-2-carboxylic acid 
• 521274-09-9 (S)-3-{{5-[[2-(tert-butoxycarbonylamino)-3-[4-((2-carboxyphenyl)amino)naphthalen-1-yl]propionyl]amino]pentyl}oxy}naphthalene-2-carboxylic acid 

Relevant academic research and scientific papers

Selective protein tyrosine phosphatatase inhibitors

Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that downregulates the insulin receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small molecule PTP1B inhibitors to treat type II diabetes has received considerable attention. In this work, NMR-based screening identified a nonselective competitive inhibitor of PTP1B. A second site ligand was also identified by NMR-based screening and then linked to the catalytic site ligand by rational design. X-ray data confirmed that the inhibitor bound with the catalytic site in the native, "open" conformation. The final compound displayed excellent potency and good selectivity over many other phosphatases. The modular approach to drug design described in this work should be applicable for the design of potent and selective inhibitors of other therapeutically relevant protein tyrosine phosphatases.

Selective protein tyrosine phosphatatase inhibitors

Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.