521274-10-2

Basic information

• Product Name: 3-[5-(2-tert-butoxycarbonylamino-3-{4-[(2-carboxy-phenyl)-hydroxyoxalyl-amino]-naphthalen-1-yl}-propionylamino)-pentyloxy]-naphthalene-2-carboxylic acid
• Synonyms: 3-[5-(2-tert-butoxycarbonylamino-3-{4-[(2-carboxy-phenyl)-hydroxyoxalyl-amino]-naphthalen-1-yl}-propionylamino)-pentyloxy]-naphthalene-2-carboxylic acid
• CAS NO: 521274-10-2
• Molecular Weight: 777.828
• Mol File: 521274-10-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[5-(2-tert-butoxycarbonylamino-3-{4-[(2-carboxy-phenyl)-hydroxyoxalyl-amino]-naphthalen-1-yl}-propionylamino)-pentyloxy]-naphthalene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[5-(2-tert-butoxycarbonylamino-3-{4-[(2-carboxy-phenyl)-hydroxyoxalyl-amino]-naphthalen-1-yl}-propionylamino)-pentyloxy]-naphthalene-2-carboxylic acid(521274-10-2)
• EPA Substance Registry System: 3-[5-(2-tert-butoxycarbonylamino-3-{4-[(2-carboxy-phenyl)-hydroxyoxalyl-amino]-naphthalen-1-yl}-propionylamino)-pentyloxy]-naphthalene-2-carboxylic acid(521274-10-2)

Safety Data

• Hazardous Substances Data: 521274-10-2(Hazardous Substances Data)

Upstream product

• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 521274-09-9 (S)-3-{{5-[[2-(tert-butoxycarbonylamino)-3-[4-((2-carboxyphenyl)amino)naphthalen-1-yl]propionyl]amino]pentyl}oxy}naphthalene-2-carboxylic acid 
• 521274-08-8 S-3-{[5-[(3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionyl)amino]pentyl]oxy}naphthalene-2-carboxylic acid methyl ester 
• 436864-61-8 S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid methyl ester 
• 436864-62-9 S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid 
• 93267-04-0 N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester 
• 75178-90-4 N-(tert-butyloxycarbonyl)-5-aminopentanol 
• 2298-07-9 4-Bromo-1-naphthylamine 

Relevant articles and documents

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that downregulates the insulin receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small molecule PTP1B inhibitors to treat type II diabetes has received considerable attention. In this work, NMR-based screening identified a nonselective competitive inhibitor of PTP1B. A second site ligand was also identified by NMR-based screening and then linked to the catalytic site ligand by rational design. X-ray data confirmed that the inhibitor bound with the catalytic site in the native, "open" conformation. The final compound displayed excellent potency and good selectivity over many other phosphatases. The modular approach to drug design described in this work should be applicable for the design of potent and selective inhibitors of other therapeutically relevant protein tyrosine phosphatases.