4371-02-2

Upstream product

• 34009-61-5 diethyl 2-methyl-2-phenylmalonate 
• 492-37-5 hydratropic acid 
• 124-38-9 carbon dioxide 
• 65749-05-5 2-methyl-2-phenylmalonic acid dimethyl ester 
• 62707-19-1 3-ethoxy-2-methyl-3-oxo-2-phenylpropanoic acid 
• 101-41-7 benzeneacetic acid methyl ester 
• 37434-59-6 dimethyl 2-phenylmalonate 
• 74-88-4 methyl iodide 

Downstream Products

• 492-37-5 hydratropic acid 
• 24131-01-9 2,2,5-trimethyl-5-phenyl-1,3-dioxane-4,6-dione 
• 109311-71-9 8-methyl-8-phenyl-6,10-dioxa-spiro[4.5]decane-7,9-dione 
• 150080-50-5 methyl-phenyl-malonyl chloride 
• 3156-07-8 methyl phenyl ketene 
• 2328-26-9 methyl (R)-2-phenylpropanoate 
• 116140-68-2 (±)-2-methyl-2-phenylmalonic acid monomethyl ester 
• 55787-79-6 N-benzyl-2-methyl-2-phenyl-malonamic acid 
• 101730-02-3 N-benzyl-2-methyl-2-phenyl-malonamic acid methyl ester 
• 7782-24-3 (S)-2-Phenylpropionic acid 
• 7782-26-5 (R)-2-Phenylpropionic acid 
• 57585-22-5 racem.-2-Ethyl-4-phenyl-pentadien-(2,3)-carbonsaeure 
• 38701-09-6 2,3-pentadienoic acid, 2-ethyl-4-phenyl-, ethyl ester 
• 5717-44-2 α,γ-Dimethyl-γ-phenyl-allencarbonsaeure-ethylester 

Relevant academic research and scientific papers

Thermolysis of 4-methyl-4-phenylmalonyl Peroxide: A New Oxygen Dependent Chemiluminescent Reaction

Thermolysis of 4-methyl-4-phenylmalonyl peroxide in acetonitrile is accelerated by electron donors, such as perylene.When both the perylene and oxygen are present in solution, the reaction gives acetophenone and a small amount of light.Investigation of th

Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

We have developed a thermally driven domino reaction for the synthesis of (S)-a-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids. Crown Copyright.

Reactions of amino-substituted cyclodextrins with 2-arylpropanoic acid derivatives

Reactions of 6A-amino-6A-deoxy-β-cyclodextrin and 3A-amino-3A-deoxy-(2AS,3 AS)-β-cyclodextrin with the 3-nitrophenyl esters of 2-phenylpropanoic acid and Ibuprofen occur with only low diastereoselectivity, to afford the corresponding arylpropanamido-substituted cyclodextrins. These amides are also formed by decarboxylation of corresponding malonates, again with only low diastereoselectivity. The n.m.r. spectra of the amido-substituted cyclodextrins indicate that the aryl substituent is included within the cyclodextrin annulus at low temperature, but becomes dissociated from the cavity as the temperature is increased.

Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

α-Methyl-α-(trifluoromethylphenyl)malonic acids have been incubated with Alcaligenes bronchisepticus to afford optically active α-arylpropionic acids.Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing.Decarboxylation of α-fluoro-α-phenylmalonic acid with the aid of the same bacterium afforded optically active α-fluoro-α-phenylacetic acid.