4374-66-7

Basic information

• Product Name: 3-hydroxy-2-phenylbutanoic acid
• Synonyms: 3-hydroxy-2-phenylbutanoic acid
• CAS NO: 4374-66-7
• Molecular Weight: 180.203
• Mol File: 4374-66-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-2-phenylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2-phenylbutanoic acid(4374-66-7)
• EPA Substance Registry System: 3-hydroxy-2-phenylbutanoic acid(4374-66-7)

Safety Data

• Hazardous Substances Data: 4374-66-7(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 75-07-0 acetaldehyde 
• 31491-21-1 2-phenyl-1,1-bis(trimethylsilyloxy)ethene 
• 40596-14-3 (±)-(2R,3S)-3-phenylpent-4-en-2-ol 
• 40596-14-3 anti-3-phenyl-4-hydroxy-1-pentene 
• 1068-55-9 isopropylmagnesium chloride 
• 114-70-5 sodium phenylacetate 
• 101-41-7 benzeneacetic acid methyl ester 
• 5413-05-8 ethyl 2-phenylacetoacetate 
• 16141-22-3 ethyl 3-hydroxy-2-phenylbutanoate 

Downstream Products

• 101450-26-4 (+/-)-erythro-3-hydroxy-2-phenyl-butyric acid-(2-diethylamino-ethyl ester) 
• 873-66-5 1-propenylbenzene 
• 19878-97-8 α-(1-Hydroxyethyl)benzenessigsaeure-methylester 
• 70982-83-1 trans-4-Methyl-3-phenyl-2-oxetanon 
• 100939-25-1 α-(1-Hydroxyethyl)benzenessigsaeure-methylester 
• 766-90-5 cis-1-phenyl-1-propylene 
• 82575-05-1 (2S,3S)-3-Hydroxy-2-phenyl-butyratetetramethyl-ammonium; 
• 70982-83-1 4-methyl-3-phenyloxetan-2-one 
• 124781-92-6 2-cyclohexyl-3-hydroxybutanoic acid 

Relevant articles and documents

PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS

The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

ERYTHROSELECTIVITY IN ADDITION OF γ-SUBSTITUTED ALLYLSILANES TO ALDEHYDES IN THE PRESENCE OF TITANIUM CHLORIDE

(E)-Crotyltrimethylsilane and (E)-cinnamyltrimethylsilane were allowed to react with aldehydes (RCHO: t-Bu, i-Pr, Et, Me) in the presence of titanium chloride to give erythro homoallyl alcohols with over 93percent selectivity.Lower erythroselectivity was observed in the reaction of (Z)-allylsilanes.