437612-88-9Relevant academic research and scientific papers
Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses
Gudmundsson, Kristjan S.,Johns, Brian A.,Wang, Zhicheng,Turner, Elizabeth M.,Allen, Scott H.,Freeman, George A.,Boyd Jr., F. Leslie,Sexton, Connie J.,Selleseth, Dean W.,Moniri, Kelly R.,Creech, Katrina L.
, p. 5346 - 5361 (2007/10/03)
Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity aga
Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents
Johns, Brian A.,Gudmundsson, Kristjan S.,Turner, Elizabeth M.,Allen, Scott H.,Samano, Vicente A.,Ray, John A.,Freeman, George A.,Boyd Jr., F. Leslie,Sexton, Connie J.,Selleseth, Dean W.,Creech, Katrina L.,Moniri, Kelly R.
, p. 2397 - 2411 (2007/10/03)
A novel series of potent pyrazolo[1,5-a]pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage interm
