437655-86-2Relevant academic research and scientific papers
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]-amino]-5-oxazolyl]phenyl]-N- methyl-4-morpholinea0cetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity
Dhar, T.G. Murali,Shen, Zhongqi,Guo, Junqing,Liu, Chunjian,Watterson, Scott H.,Gu, Henry H.,Pitts, William J.,Fleener, Catherine A.,Rouleau, Katherine A.,Sherbina,McIntyre, Kim W.,Witmer, Mark R.,Tredup, Jeffrey A.,Chen, Bang-Chi,Zhao, Rulin,Bednarz, Mark S.,Cheney, Daniel L.,MacMaster, John F.,Miller, Laura M.,Berry, Karen K.,Harper, Timothy W.,Barrish, Joel C.,Hollenbaugh, Diane L.,Iwanowicz, Edwin J.
, p. 2127 - 2130 (2007/10/03)
Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme that is involved in the de novo synthesis of purine nucleotides. Novel 2-aminooxazoles were synthesized and tested for inhibition of IMPDH catalytic activity. Multiple analogues based on this che
A Modified Approach to 2-(N-Aryl)-1,3-oxazoles: Application to the Synthesis of the IMPDH Inhibitor BMS-337197 and Analogues
Dhar, T. G. Murali,Guo, Junqing,Shen, Zhongqi,Pitts, William J.,Gu, Henry H.,Chen, Bang-Chi,Zhao, Rulin,Bednarz, Mark S.,Iwanowicz, Edwin J.
, p. 2091 - 2093 (2007/10/03)
(Matrix Presented) A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described
