901335-15-7Relevant articles and documents
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]-amino]-5-oxazolyl]phenyl]-N- methyl-4-morpholinea0cetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity
Dhar, T.G. Murali,Shen, Zhongqi,Guo, Junqing,Liu, Chunjian,Watterson, Scott H.,Gu, Henry H.,Pitts, William J.,Fleener, Catherine A.,Rouleau, Katherine A.,Sherbina,McIntyre, Kim W.,Witmer, Mark R.,Tredup, Jeffrey A.,Chen, Bang-Chi,Zhao, Rulin,Bednarz, Mark S.,Cheney, Daniel L.,MacMaster, John F.,Miller, Laura M.,Berry, Karen K.,Harper, Timothy W.,Barrish, Joel C.,Hollenbaugh, Diane L.,Iwanowicz, Edwin J.
, p. 2127 - 2130 (2002)
Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme that is involved in the de novo synthesis of purine nucleotides. Novel 2-aminooxazoles were synthesized and tested for inhibition of IMPDH catalytic activity. Multiple analogues based on this che