437716-09-1

Basic information

• Product Name: 4(1H)-Quinolinone, 2-[[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]amino]-
• CAS NO: 437716-09-1
• Molecular Formula: C19H19Cl2N3O
• Molecular Weight: 376.285
• Mol File: 437716-09-1.mol

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinolinone, 2-[[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinolinone, 2-[[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]amino]-(437716-09-1)
• EPA Substance Registry System: 4(1H)-Quinolinone, 2-[[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]amino]-(437716-09-1)

Safety Data

• Hazardous Substances Data: 437716-09-1(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 102-49-8 3,4-dichlorobenzyl amine 
• 248607-96-7 N₁-(4-(4-methoxybenzyloxy)quinolin-2-yl)propane-1,3-diamine 
• 4295-08-3 2-Chloro-4-ethoxyquinoline 
• 733053-60-6 2-chloro-4-(4-methoxybenzyloxy)quinoline 
• 703-61-7 2,4-dichloroquinoline 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Relevant articles and documents

Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives

In this study, a novel benzothiazol- and benzooxazol-2-amine scaffold with antibacterial activity was designed and synthesized. Preliminary structure-activity relationship analysis displayed that compound 8t with a 5,6-difluorosubstituted benzothiazole was found to be a potent inhibitor of Gram-positive pathogens, and exhibited some potential against drug-resistant bacteria and without cytotoxicity in therapeutic concentrations. In addition, molecular docking studies indicated that Staphylococcus aureus methionyl-tRNA synthetase might be the possible target of these compounds. Taken together, the present study provides an effective entry to the synthesis of a good lead for subsequent optimization and a new small molecule candidate drug for antibacterial therapeutics.

Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.

UROTENSIN-II RECEPTOR ANTAGONISTS

The present invention relates to a method of antagonizing the Urotensin-II receptor by 2-(NH-substituted) quinolones.

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent Gram-positive antibacterial activity

Optimisation of the left-hand-side aryl moiety of a file compound screening hit against Staphylococcus aureus methionyl tRNA synthetase led to the identification of a series of potent nanomolar inhibitors. The best compounds showed excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics.