437755-80-1Relevant academic research and scientific papers
Peptidyl α-Ketoheterocyclic Inhibitors of Human Neutrophil Elastase. 3. In Vitro and in Vivo Potency of a Series of Peptidyl α-Ketobenzoxazoles
Edwards, Philip D.,Zottola, Mark A.,Davis, Matthew,Williams, Joseph,Tuthill, Paul A.
, p. 3972 - 3982 (1995)
A series of peptidyl α-ketobenzoxazoles were synthesized and evaluated for their in vitro and in vivo inhibition of human neutrophil elastase (HNE).These compounds inhibit HNE by forming both a covalent bond between the ketone carbonyl carbon atom and the
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen der p 1: An innovative approach to the treatment of allergic asthma
Newton, Gary K.,Perrior, Trevor R.,Jenkins, Kerry,Major, Meriel R.,Key, Rebekah E.,Stewart, Mark R.,Firth-Clark, Stuart,Lloyd, Steven M.,Zhang, Jihui,Francis-Newton, Nicola J.,Richardson, Jonathan P.,Chen, Jie,Lai, Pei,Garrod, David R.,Robinson, Clive
, p. 9447 - 9462 (2015/01/16)
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously. Group 1 allergens of house dust mites (HDM) are meaningful targets in this quest because they are globally prevalent and clinically important triggers of allergic asthma. Group 1 HDM allergens are cysteine peptidases whose proteolytic activity triggers essential steps in the allergy cascade. Using the HDM allergen Der p 1 as an archetype for structure-based drug discovery, we have identified a series of novel, reversible inhibitors. Potency and selectivity were manipulated by optimizing drug interactions with enzyme binding pockets, while variation of terminal groups conferred the physicochemical and pharmacokinetic attributes required for inhaled delivery. Studies in animals challenged with the gamut of HDM allergens showed an attenuation of allergic responses by targeting just a single component, namely, Der p 1. Our findings suggest that these inhibitors may be used as novel therapies for allergic asthma.
