Peptidyl α-Ketoheterocyclic Inhibitors of Human Neutrophil Elastase. 3. In Vitro and in Vivo Potency of a Series of Peptidyl α-Ketobenzoxazoles

Article abstract of DOI:10.1021/jm00020a011

A series of peptidyl α-ketobenzoxazoles were synthesized and evaluated for their in vitro and in vivo inhibition of human neutrophil elastase (HNE).These compounds inhibit HNE by forming both a covalent bond between the ketone carbonyl carbon atom and the