Journal of Medicinal Chemistry p. 3972 - 3982 (1995)
Update date:2022-09-26
Topics:
Edwards, Philip D.
Zottola, Mark A.
Davis, Matthew
Williams, Joseph
Tuthill, Paul A.
A series of peptidyl α-ketobenzoxazoles were synthesized and evaluated for their in vitro and in vivo inhibition of human neutrophil elastase (HNE).These compounds inhibit HNE by forming both a covalent bond between the ketone carbonyl carbon atom and the
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