437763-91-2

Upstream product

• 185540-07-2 1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid 
• 239099-53-7 1-butyl-3-amino-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine 
• 501690-38-6 3-amino-1-butyl-4-(3-hydroxy-phenyl)-1H-[1,8]naphthyridin-2-one 
• 437763-89-8 acetic acid 3-[3-(3-amino-1-butyl-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-propyl ester 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 873194-84-4 acetic acid 3-[3-(1-butyl-3-{3-[2,6-diisopropyl-3-(trityl-amino)-phenyl]-ureido}-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-propyl ester 
• 873194-83-3 acetic acid 4-[3-(1-butyl-3-{3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-ureido}-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-butyl ester 
• 873194-82-2 acetic acid 3-[3-(1-butyl-3-{3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-ureido}-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-propyl ester 

Relevant academic research and scientific papers

Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)- on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility

4-Aryl-1,8-naphthyridin-2(1H)-on-3-yl urea derivatives with hydrophilic groups were synthesized in order to improve aqueous solubility and pharmacokinetic property. SMP-797 possessing (4-aminophenyl)ureido and 3-(hydroxypropoxyphenyl) moieties showed pote