185540-07-2

Upstream product

• 945589-46-8 N-{3-[hydroxy(3-methoxyphenyl)methyl]pyridin-2-yl}pivalamide 
• 591-31-1 3-methoxy-benzaldehyde 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 239099-70-8 1-butyl-3-ethoxycarbonyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine 

Downstream Products

• 185539-34-8 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea 
• 873194-95-7 1-{1-butyl-2-oxo-4-[3-(3-piperidin-1-yl-propoxy)-phenyl]-1,2-dihydro-[1,8]naphthyridin-3-yl}-3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-urea 
• 873194-94-6 1-{1-butyl-2-oxo-4-[3-(3-pyrrolidin-1-yl-propoxy)-phenyl]-1,2-dihydro-[1,8]naphthyridin-3-yl}-3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-urea 
• 873194-93-5 1-{1-butyl-4-[3-(3-diethylamino-propoxy)-phenyl]-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl}-3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-urea 
• 873194-83-3 acetic acid 4-[3-(1-butyl-3-{3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-ureido}-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-butyl ester 
• 873194-82-2 acetic acid 3-[3-(1-butyl-3-{3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-ureido}-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-propyl ester 
• 873194-84-4 acetic acid 3-[3-(1-butyl-3-{3-[2,6-diisopropyl-3-(trityl-amino)-phenyl]-ureido}-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-propyl ester 
• 873194-81-1 acetic acid 2-[3-(1-butyl-3-{3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-ureido}-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-ethyl ester 
• 873194-89-9 1-{1-butyl-4-[3-(3-chloro-propoxy)-phenyl]-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl}-3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-urea 
• 259225-25-7 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-tritylaminophenyl)urea 
• 873194-73-1 1-[1-butyl-4-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl]-3-[2,6-diisopropyl-3-(trityl-amino)-phenyl]-urea 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT)

The synthesis and structure-activity relationships of N-phenyl-N′-[3- (4-phenylnaphthylidinoyl)]urea derivatives 3 as a novel structural class of potent ACAT inhibitors is described. A 3-methoxy group substituted on the naphthylidinone 4-phenyl ring, toge

NOVEL NAPHTHYRIDINE DERIVATIVES

Naphthyridine derivative of the formula: wherein Ring A is substituted or unsubstituted pyridine ring, X is ―N(R2)―CO― (R2is H, alkyl, substituted alkyl, etc.), Z is a direct bond, ―NH―, C1-2alkylene, or ―CH=CH―, Y is aromatic group or substituted aromatic group, L is alkyl, substituted alkyl, aromatic group or substituted aromatic group, or an acid addition salt thereof, these compounds exhibiting acyl-CoA: cholesterol acyl transferase inhibitory activity, and being useful as an agent for prophylaxis or treatment of hyperlipidemia, atherosclerosis, and related diseases thereof.

Naphthyridine derivatives

Naphthyridine derivative of the formula: STR1 wherein Ring A is substituted or unsubstituted pyridine, X is --N(R2)--CO--(R2 is H, alkyl, substituted alkyl, etc.), Z is a direct bond, --NH--, C1 -C2 alkylene, or --CH=CH--, Y is alkyl, substituted alkyl, aromatic group or substituted aromatic group, etc., B is alkyl, substituted alkyl, aromatic group or substituted aromatic group, or an acid addition salt thereof, these compounds having acyl-CoA: cholesterol acyl transferase inhibitory activity, and being useful as an agent for prophylaxis or treatment of hyperlipidemia, atherosclerosis, and related diseases thereof.