239099-53-7

Upstream product

• 67-63-0 isopropyl alcohol 
• 239099-42-4 2-(butylamino)-3-(3-methoxybenzoyl)pyridine 
• 4702-13-0 N-phthaloylglycine 
• 74-89-5 methylamine 
• 185540-07-2 1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid 

Downstream Products

• 501690-38-6 3-amino-1-butyl-4-(3-hydroxy-phenyl)-1H-[1,8]naphthyridin-2-one 
• 873194-72-0 [1-butyl-4-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl]-carbamic acid phenyl ester 
• 873194-88-8 3-amino-1-butyl-4-[3-(3-chloro-propoxy)-phenyl]-1H-[1,8]naphthyridin-2-one 
• 873194-79-7 acetic acid 2-[3-(3-amino-1-butyl-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-ethyl ester 
• 437763-89-8 acetic acid 3-[3-(3-amino-1-butyl-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-propyl ester 
• 873194-80-0 acetic acid 4-[3-(3-amino-1-butyl-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-butyl ester 
• 437763-91-2 acetic acid 3-[3-(1-butyl-2-oxo-3-phenoxycarbonylamino-1,2-dihydro-[1,8]naphthyridin-4-yl)-phenoxy]-propyl ester 
• 259225-21-3 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea 
• 259224-74-3 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-hydroxymethylphenyl)urea 
• 259225-20-2 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-[2,6-diisopropyl-4-(tert-butyldimethylsilyloxymethyl)phenyl]urea 
• 259225-22-4 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-phthalimidomethylphenyl)-urea 
• 873194-73-1 1-[1-butyl-4-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl]-3-[2,6-diisopropyl-3-(trityl-amino)-phenyl]-urea 
• 259225-25-7 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-tritylaminophenyl)urea 

Relevant academic research and scientific papers

Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)- on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility

4-Aryl-1,8-naphthyridin-2(1H)-on-3-yl urea derivatives with hydrophilic groups were synthesized in order to improve aqueous solubility and pharmacokinetic property. SMP-797 possessing (4-aminophenyl)ureido and 3-(hydroxypropoxyphenyl) moieties showed pote

Preparation of pyridone derivatives using phthalimido containing starting material

A process for preparing a pyridone derivative (4), which comprises reacting the compound (1) with a hypochlorite or a hypobromite or with lead tetraacetate to give the compound (2), and reacting the compound (2) with the compound (3). Said process is preferably especially from the standpoint of safety. wherein R1is hydrogen, alkyl, substituted alkyl, etc.; Y1is hydrogen, alky, substituted alky, etc.; Y2and Y3are indenpently hydrogen, halogen, etc.; and L is alkyl, substituted alky, etc.