438208-22-1Relevant academic research and scientific papers
INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF
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Page/Page column 199; 200, (2013/02/27)
The present invention relates to a novel indazole- or pyrrolopyridine-derivative, represented by the formula (1) below, that has an agonistic action or a partial agonistic action against serotonin-4 receptor, and a pharmaceutical composition comprising the same. Formula (1) [wherein each substituent is as defined in claim 1]
CHEMOKINE RECEPTOR BINDING COMPOUNDS
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Page/Page column 34, (2008/12/06)
Compounds that modulate the activity of chemokine receptors, in particular CCR5, are disclosed.
Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity
Palani, Anandan,Shapiro, Sherry,Josien, Hubert,Bara, Thomas,Clader, John W.,Greenlee, William J.,Cox, Kathleen,Strizki, Julie M.,Baroudy, Bahige M.
, p. 3143 - 3160 (2007/10/03)
We previously reported the discovery of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl-3 -pyridinyl)carbonyl]-4′-methyl-1,4′-bipipefidine N-oxide 1 (SCH 351125) as an orally bioavailable human CCR5 antagonist for the treatment of HIV-1 infec
