4385-72-2

Upstream product

• 110-86-1 pyridine 
• 4334-88-7 p-ethoxycarbonylphenylboronic acid 
• 113964-72-0 triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 1692-15-5 4-pyridylboronic acid 

Downstream Products

• 853680-69-0 {2-[(4-chlorobenzyl)-(4-pyridin-4-yl-benzoyl)-amino]-ethyl}-carbamic acid tert-butyl ester 
• 853686-95-0 N-(2-amino-ethyl)-N-(4-chlorobenzyl)-4-pyridin-4-yl-benzamide 
• 4385-76-6 4-(4-pyridinyl)benzoic acid 

Relevant academic research and scientific papers

Tunable Second-Level Room-Temperature Phosphorescence of Solid Supramolecules between Acrylamide–Phenylpyridium Copolymers and Cucurbit[7]uril

A series of solid supramolecules based on acrylamide–phenylpyridium copolymers with various substituent groups (P?R: R=?CN, ?CO2Et, ?Me, ?CF3) and cucurbit[7]uril (CB[7]) are constructed to exhibit tunable second-level (from 0.9 s to

Phosphonium Salts as Pseudohalides: Regioselective Nickel-Catalyzed Cross-Coupling of Complex Pyridines and Diazines

Heterobiaryls are important pharmacophores that are challenging to prepare by traditional cross-coupling methods. An alternative approach is presented where pyridines and diazines are converted into heteroaryl phosphonium salts and coupled with aryl boronic acids. Nickel catalysts are unique for selective heteroaryl transfer, and the reaction has a broad substrate scope that includes complex pharmaceuticals. Phosphonium ions also display orthogonal reactivity in cross-couplings compared to halides, enabling chemoselective palladium- and nickel-catalyzed coupling sequences.

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Synthesis of functionalized 4-phenyl-pyridines via electrochemically prepared organozinc reagents

The efficient and convenient synthesis of various functionalized 4-phenyl-pyridines 2 is described. The key step of the procedure is the electrochemical formation of aromatic organozinc reagents 1 and their coupling with pyridinium salts. Intermediate 1,4