438545-36-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(1H-Imidazol-2-yl)-thiazole is used as a building block for the synthesis of various pharmaceuticals due to its versatile reactivity and the presence of potentially bioactive functional groups. Its incorporation into drug molecules can enhance their therapeutic properties and contribute to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(1H-Imidazol-2-yl)-thiazole is utilized as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its versatile reactivity and bioactive functional groups can improve the effectiveness of these products and contribute to more sustainable agricultural practices.
Used in Antimicrobial Applications:
2-(1H-Imidazol-2-yl)-thiazole is used as an antimicrobial agent for its antifungal and antibacterial properties. It can be incorporated into new drugs to combat resistant strains of bacteria and fungi, addressing the growing issue of antibiotic resistance.
Used in Medicinal Chemistry Research:
As a compound containing imidazole and thiazole rings, 2-(1H-Imidazol-2-yl)-thiazole is used in medicinal chemistry research to explore its wide-ranging pharmacological activity. The study of its structure and properties can lead to the discovery of new drug candidates and contribute to the advancement of medical treatments.

InChI:InChI=1/C6H5N3S/c1-2-8-5(7-1)6-9-3-4-10-6/h1-4H,(H,7,8)

Upstream product

• 1452-16-0 thiazole-2-carbonitrile 
• 22483-09-6 2,2-dimethoxyethylamine 
• 438554-20-2 2-(1-ethoxymethyl-1H-imidazol-2-yl)-thiazole 

Downstream Products

• 627910-68-3 3-methoxy-5-phenyl-2-(2-thiazol-2-yl-imidazol-1-ylmethyl)-pyrazine 

Relevant academic research and scientific papers

PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE

The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

A simple and convenient one-pot method for the preparation of heteroaryl-2-imidazoles from nitriles

A simple, convenient and high-yielding one-pot method for the synthesis of 2-heterocycle-substituted imidazoles from the corresponding nitriles has been developed. The procedure is easily scaleable and the workup does not involve chromatography. This synthesis is also applicable to the preparation of imidazoles with electron-poor aryl substituents.

Substituted ring-fused imidazole derivative: GABAA receptors ligands

Substituted ring-fused imidazole derivatives that bind to GABAA receptors are provided. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a v

Substituted imidazolylmethyl pyridine and pyrazine deriviatives GABAa receptor ligands

Substituted imidazolylmethyl pyridine and pyrazine derivatives that bind to GABAA receptors are provided. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

Benzimidazole and pyridylimidazole derivatives

This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

Heteroaryl substituted fused bicyclic heteroaryl compound as GABAA receptor ligands

This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or F