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Elobixibat is an ileal sodium-dependent bile acid transporter (IBAT) inhibitor, primarily utilized in the treatment of chronic constipation and irritable bowel syndrome with constipation (IBS-C). It functions by inhibiting the IBAT, which results in the increased absorption of bile acids in the ileum, thereby improving bowel movement and alleviating constipation symptoms.

439087-18-0

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439087-18-0 Usage

Uses

Used in Pharmaceutical Industry:
Elobixibat is used as a therapeutic agent for the treatment of chronic constipation. It helps to alleviate the symptoms by enhancing bowel movement through the inhibition of ileal sodium-dependent bile acid transporters.
Elobixibat is also used as a therapeutic agent for the treatment of irritable bowel syndrome with constipation (IBS-C). By inhibiting the IBAT, it aids in improving the frequency of bowel movements and reducing abdominal discomfort associated with IBS-C.

Check Digit Verification of cas no

The CAS Registry Mumber 439087-18-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,9,0,8 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 439087-18:
(8*4)+(7*3)+(6*9)+(5*0)+(4*8)+(3*7)+(2*1)+(1*8)=170
170 % 10 = 0
So 439087-18-0 is a valid CAS Registry Number.

439087-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[[(2R)-2-[[2-[(3,3-dibutyl-7-methylsulfanyl-1,1-dioxo-5-phenyl-2,4-dihydro-1λ<sup>6</sup>,5-benzothiazepin-8-yl)oxy]acetyl]amino]-2-phenylacetyl]amino]acetic acid

1.2 Other means of identification

Product number -
Other names Glycine,(2R)-N-(2-((3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,5-benzothiazepin-8-yl)oxy)acetyl)-2-phenylglycyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:439087-18-0 SDS

439087-18-0Downstream Products

439087-18-0Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF 1,5-BENZOTHIAZEPINE COMPOUNDS

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, (2019/09/20)

The present invention relates to a process for the preparation of certain 1,5-benzothiazepine compounds, and in particular to a process for the preparation of elobixibat. The process can be carried out under mild and safe conditions and may be used to pre

Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease

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, (2013/05/09)

Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI)

Chemical compounds

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, (2008/06/13)

The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described. 1

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