439108-46-0

Upstream product

• 536-74-3 phenylacetylene 
• 20062-24-2 4-azidoacetophenone 
• 99-92-3 p-aminobenzophenone 
• 99-90-1 para-bromoacetophenone 
• 350-47-0 1-(4-acetylphenyl)diazonium tetrafluoroborate 
• 149104-90-5 4-acetylphenylboronic acid 
• 7436-90-0 2,2-dibromostyrene 
• 100-19-6 (4-nitrophenyl)ethanone 
• 103-64-0 bromostyrene 

Relevant academic research and scientific papers

Immobilization of vitamin B1 on the magnetic dialdehyde starch as an efficient carbene-type support for the copper complexation and its catalytic activity examination

Since the starch biopolymer is an available and inexpensive matrix with modifiable functionality and stabilization capability for metal ions, in this report, we oxidized it to dialdehyde form for the further functionalization with vitamin B1 as a green σ-donor and π-acceptor carbene type ligand. Immobilization of vitamin B1 on this biopolymer was done through imine bond formation between NH2 groups of aminopyrimidine segment of vitamin B1 and aldehyde functional groups of starch oxide. Thiazolium heterocycle part in this biomolecule provided a carbene type precursor for the metal complexation. After the magnetization process by using of Fe3O4 nanoparticles that lead to quick and facile magnetic separation and metal catalyst recycling, copper ions immobilized on the magnetic support (5.9 wt% Cu, 0.93 mmol/g). The prepared copper N-heterocyclic carbene complex (Fe3O4@DAS@VB1@CuCl nanocomposite) was characterized by FT-IR, SEM, EDX, XRD, VSM, TGA and ICP-OES analysis and then its catalytic activity investigated in azidonation of arylboronic acids and also one-pot coupling reaction of the synthesized aryl azides with phenylacetylene. 1,4-Diaryl 1,2,3-triazoles were obtained in excellent yields (≥90%) at proper reaction times (30–200 min). The magnetic catalyst was recovered by a magnetic field and reused in azidation reaction up to 7 cycle.

A sustainable approach for efficient one-pot synthesis of 1-aryl 1,2,3-triazoles using copper iodide supported on 3-thionicotinyl-urea-modified magnetic nanoparticles in DES

An efficient and retrievable copper(I) catalyst was synthesized by immobilizing of copper iodide on 3-thionicotinyl-urea-modified magnetic nanoparticles and characterized using a variety of analysis techniques. The catalytic activity of these nanoparticle

Preparation of aryl azides of aryl boronic acids and one-pot synthesis of 1,4-diaryl-1,2,3-triazoles by a magnetic cysteine functionalized GO–CuI/II nanocomposite

A mixed CuI/CuIIcatalyst based on magnetic cysteine functionalized graphene oxide (CuI/II@Cys-MGO) was prepared and used for the azidonation reaction of aryl boronic acids and one-pot synthesis of 1,4-diaryl ?1,2,3-triazoles. Aryl azides were obtained in good yields and short reaction times via cross-coupling of aryl boronic acids with sodium azide in the presence of CuII catalytic species in this catalytic system. The azide-alkyne cycloaddition reaction was catalyzed by CuI catalytic species in CuI/II@Cys-MGO nanocomposite.

Method for preparing 1,2,3-triazole compound by heterogeneous copper catalysis in one pot

The invention relates to a method for preparing a 1-aryl-4-substituted-1,2,3-triazole compound shown as a formula (II). The method comprises the following steps: mixing arylboronic acid (1), NaN3, a heterogeneous copper catalyst and solvent water, performing a stirring reaction at 25-60 DEG C for 4-8 hours, performing TLC (thin-layer chromatography) monitoring till the arylboronic acid (1) is completely converted, replacing air in the reaction system by using N2, adding a terminal alkyne (2), performing a reaction at 40-80 DEG C for 6-10 hours under the protection of N2, and performing post-treatment on the reaction solution to obtain a product (II). By adopting the preparation method, Cu-coated SBA-15-PTAA is used as a catalyst, a series of 1-aryl-4-substituted-1,2,3-triazole compounds are prepared through a one-pot Chan-Lam/Click series method without additionally adding a reducing agent, the developed catalytic method is green, safe and economical, the amount of three wastes (wastegas, waste water and industrial residue) is small, the yield of a target product is high, and the substrate application range is wide.

A bromobenzene ethylene synthesis by β - 1, 2, 3 - triazole method

The invention discloses a bromobenzene ethylene synthesis of β - 1, 2, 3 - triazole method, synthetic method comprises the following steps: adding to the reaction container in the β - bromophenylacetic vinyl compounds, additive, nitrobenzene compounds, azide, catalyst, sodium ascorbate and organic solvent; under the protection of nitrogen reaction; to be after completion of the reaction, post-processing, by recrystallization or silica gel column chromatography purification to obtain the 1, 2, 3 - triazole class compound; catalyst is a monovalent copper salt or a bivalent copper salt, can be cuprous iodide or copper sulfate and the like. The present invention has high safety, simple operation, mild condition, low cost, easy to industrial production and the like.

Method for preparing 1,2,3-triazole through dibromo-vinyl benzene one-pot process

The invention discloses a method for preparing 1,2,3-triazole through a dibromo-vinyl benzene one-pot process. The synthesis method comprises the following steps that a 2,2-dibromo-vinyl benzene compound, sodium azide, a nitrobenzene compound, alkali, a c

CuFeO2/tetrabutylammonium bromide catalyzes selective synthesis of 1,4-disubstituted 1,2,3-triazoles in neat water at room temperature

A completely green medium including water as a solvent and antiviral CuFeO2 as a catalyst is described for the synthesis of 1,4-disubstituted 1,2,3-triazoles. Excellent yields of products are obtained at room temperature. Cost effectiveness, hi

Copper(I)–Phosphinite Complexes in Click Cycloadditions: Three-Component Reactions and Preparation of 5-Iodotriazoles

The remarkable activity displayed by copper(I)–phosphinite complexes of general formula [CuBr(L)] in two challenging cycloadditions is reported: a) the one-pot azidonation/cycloaddition of boronic acids, NaN3, and terminal alkynes; b) the cyclo

Polyvinyl alcohol-stabilized cuprous oxide particles: efficient and recyclable heterogeneous catalyst for azide-alkyne cycloaddition in water at room temperature

Abstract The PVA-stabilized Cu2O particles were prepared using a novel and simple rout in aqueous medium at room temperature under aerobic conditions. Initially, Cu(II) ions were fixed in PVA matrix via complex formation with OH groups, subsequ

Chemoselective reduction of the carbonyl functionality through hydrosilylation: Integrating click catalysis with hydrosilylation in one pot

Herein we report the chemoselective reduction of the carbonyl functionality via hydrosilylation using a copper(I) catalyst bearing the abnormal N-heterocyclic carbene 1 with low (0.25 mol %) catalyst loading at ambient temperature in excellent yield within a very short reaction time. The hydrosilylation reaction of α,β-unsaturated carbonyl compounds takes place selectively toward 1,2-addition (C=O) to yield the corresponding allyl alcohols in good yields. Moreover, when two reducible functional groups such as imine and ketone groups are present in the same molecule, this catalyst selectively reduces the ketone functionality. Further, 1 was used in a consecutive fashion by combining the Huisgen cycloaddition and hydrosilylation reactions in one pot, yielding a range of functionalized triazole substituted alcohols in excellent yields.