4392-36-3Relevant academic research and scientific papers
Sulfonyl azides acylsulfonamide derivatives and their use for production of derivative.
-
Paragraph 0033-0034, (2017/06/03)
PROBLEM TO BE SOLVED: To provide a click reaction having bioorthogonality and high versatility.SOLUTION: Sulfonyl amidines and acylsulfonamides are manufactured by using thioamide and sulfonyl azide. The reaction is a novel click reacting having no need of additives and bioorthogonality and high versatility with proceeding under a mild condition and in a solution.
Coupling reaction of thioamides with sulfonyl azides: An efficient catalyst-free click-type ligation under mild conditions
Aswad, Muhammad,Chiba, Junya,Tomohiro, Takenori,Hatanaka, Yasumaru
supporting information, p. 10242 - 10244 (2013/10/22)
We report a coupling reaction of thioamides and sulfonyl azides to generate sulfonyl amidines in the absence of any activation additives. The reaction progresses in various solvents under mild conditions. Water exhibits the highest performance with respect to efficiency.
Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase
Maccallim, Cristina,Patruno, Antonia,Be?ker, Neva,Alì, Jamila Isabella,Ammazzalorso, Alessandra,De Filippis, Barbara,Franceschelli, Sara,Giampietro, Letizia,Pesce, Mirko,Reale, Marcella,Tricca, Maria L.,Re, Nazzareno,Felaco, Mario,Amoroso, Rosa
supporting information; experimental part, p. 1481 - 1485 (2009/12/26)
New acetamidines structurally related to N-(3-(aminomethyl)benzyl) acetamidine (1, W1400) were designed as inhibitors of inducible nitric oxide synthase (iNOS). Six compounds were found to be selective for iNOS over endothelial nitric oxide synthase (eNOS), and among them, the most active and selective compound was the N-benzylacetamidine 2. A docking study was also performed to shed light on the effects of the structural modifications on the interaction of the designed inhibitors with the NOS.
