439264-88-7

Upstream product

• 250226-97-2 (2R,4aR,9aS)-2-Phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-one 
• 439265-02-8 Trifluoro-methanesulfonic acid (2R,4aR,9aS)-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl ester 
• 439264-87-6 4-((2R,4aR,9aS)-2-Phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-butyric acid ethyl ester 
• 213815-32-8 (2R,4aR,6S,7R,9aS)-2-Phenyl-6-vinyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol 

Downstream Products

• 439264-89-8 4-((2R,4aR,5aS,10aR,12aS)-2-Phenyl-4a,5a,6,7,10a,11,12,12a-octahydro-4H-1,3,5,10-tetraoxa-benzo[b]heptalen-9-yl)-butyric acid ethyl ester 

Relevant academic research and scientific papers

Design and synthesis of simplified polycyclic ethers and evaluation of their interaction with an α-helical peptide as a model of target proteins

Two simplified pentacyclic ethers, having 6/7/6/6/7 and 6/7/6/7/7 ring systems, were synthesized. A convergent route based on the Suzuki-Miyaura cross-coupling strategy was applied to synthesize these two compounds. Interactions between α-helical peptide,

Concise synthesis of cyclic ethers via the palladium-catalyzed coupling of ketene acetal triflates and organozinc reagents. Application to the iterative synthesis of polycyclic ethers

The reaction of the ketene acetal triflates 9a-e and a zinc homoenolate 10 in the presence of a catalytic amount of Pd(PPh3)4 gave the enol ethers 11a-e in good yields. The products were converted to the corresponding cyclic ethers 1