439277-54-0

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 7521-41-7 2-Aminonicotinaldehyde 
• 439277-53-9 2-amino-3-(4-chlorophenyl)-1,8-naphthyridine 

Downstream Products

• 439277-55-1 2-chloro-3-(4-chlorophenyl)-1,8-naphthyridine 
• 1246467-04-8 ethyl [2-oxo-3-(4-chlorophenyl)-2H-[1,8]-naphthyridin-1-yl]acetate 
• 1246467-20-8 C₂₃H₁₄Cl₂N₄O₂ 
• 1246467-21-9 C₂₃H₁₄Cl₂N₄O₂ 
• 1246467-22-0 C₂₃H₁₃Cl₃N₄O₂ 
• 1246467-23-1 C₂₃H₁₃Cl₃N₄O₂ 
• 1246467-24-2 C₂₃H₁₄BrClN₄O₂ 
• 1246467-25-3 C₂₃H₁₄ClN₅O₄ 
• 1246467-26-4 C₂₃H₁₄ClN₅O₄ 
• 1246467-27-5 C₂₅H₁₉ClN₄O₄ 
• 1246467-28-6 C₂₄H₁₅ClN₄O₄ 
• 1246467-05-9 C₂₃H₁₇ClN₄O₂ 
• 1246467-06-0 C₂₄H₁₉ClN₄O₂ 
• 1246467-07-1 C₂₄H₁₉ClN₄O₃ 

Relevant academic research and scientific papers

An Exceedingly Mild, Green Synthesis of Substituted N-3-diaryl-1,8-naphthyridin-2-amine Derivatives and Their Antimicrobial Activity

An exceedingly and highly efficient procedure has been described for the synthesis of substituted N-3-diaryl-1,8-naphthyridin-2-amines by the reaction of 2-chloro-3-aryl-1,8-naphthyridines with various anilines in the presence of N-methyl-2-pyrrolidone and K2CO3 under thermal green solvent-free conditions. The significant features of this green reaction include very good yields in purity, simple experimental, short reaction time, easy workability, and avoidance of toxic solvents. All synthesized compounds have been evaluated for their antibacterial activity.

An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity

The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.

Claisen-Schmidt condensation under solventfree conditions

Claisen-Schmidt condensation of 2-(4-acetyl-phenylamino)-3(4-chlorophenyl)- 1,8-naphthyridine 3 with various aromatic aldehydes under solvent-free conditions to prepare α-βunsaturated ketones 4 using solid NaOH as catalyst has been described. The reaction proceeds efficiently at room temperature in high yields and in a state of excellent purity.

Microwave assisted synthesis of imidazo[1,2-a][1,8]Naphthyridin-1(2H)-ones

Synthesis of 2-carboxyalkylamino-3-(p-chlorophenyl)-1,8-naphthyridines and their conversion into novel imidazo [1,2-a][1,8]naphthyridin-1(2H)-ones under microwave irradiation are described.