439614-41-2Relevant academic research and scientific papers
5′-substituted-6-carboxylic-2,2′-bipyridine acid: A pivotal architecton for building preorganized ligands
Charbonniere, Loie J.,Weibel, Nicolas,Ziessel, Raymond F.
, p. 3933 - 3936 (2007/10/03)
A set of ligands bearing 6-bromo-2,2′-bipyridine pendant arms attached in the 5′-position are described. Transformation of the bromo to an ester was performed by a carboethoxylation reaction promoted by low-valent Pd(0), while saponification followed by acidification gave the acids. The introduction of an appended function 3-nitrobenzyl, benzamidomethyl, and tert-butylacetyl opens the way to further functionalize these scaffolds for potential labeling of biological material. The synthetic protocols represent a valuable approach to the rational design of ligands bearing oxophilic and anionic sidearms.
