439858-53-4

Upstream product

• 100-52-7 benzaldehyde 
• 123-38-6 propionaldehyde 
• 1246043-68-4 (5R,6R,Z)-6-hydroxy-N,N-dimethyl-5,6-diphenylhex-3-enamide 
• 636603-69-5 (2S,3S,3aS,4aS,5R,8S,8aR)-3-nitro-2-phenyl-3,5,10,10-tetramethyl-5,8-methanooctahydro-2H-isoxazolo[3,2-b]benzoxazole 
• 636603-74-2 (2S,3S,3aS,4aS,5R,8S,8aR)-2-phenyl-3,5,10,10-tetramethyl-5,8-methanooctahydro-2H-isoxazolo[3,2-b]benzoxazole 

Downstream Products

• 116126-02-4 (+)-(2S,3R)-3-hydroxy-2-methyl-3-phenylpropanoic acid 
• 139068-60-3 (2R,3R)-2-methyl-3-phenyl-1,3-propane diol 

Relevant academic research and scientific papers

Recyclable enamine catalysts for asymmetric direct cross-aldol reaction of aldehydes in emulsion media

Highly diastereo- and enantioselective cross-aldol reactions of aldehydes (>20:1 dr, 99% ee), catalyzed by chiral diamine-polyoxometalate acid combined enamine catalysts in emulsion media, are reported. This type of catalysts can be recycled several times

Microwave assisted synthesis of enantiomerically pure allylboronates

Stable allylboronates with a stereogenic centre α to the boronic ester moiety represent versatile reagents for stereoselective synthesis of homoallylic alcohols. Use of microwave irradiation in desilylation and sigmatropic rearrangement reactions allows r

Combined proline-surfactant organocatalyst for the highly diastereo- and enantioselective aqueous direct cross-aldol reaction of aldehydes

(Chemical Equation Presented) Why not combine the two? The asymmetric direct aldol reaction of two different aldehydes was catalyzed by a combined proline-surfactant organic catalyst in the presence of water. A stable emulsion was formed in the reaction mixture, and the aldols were obtained with excellent diastereo- and enantioselectivities (see scheme).

[2+3] Cycloadditions between nitroalkenes and camphor-derived oxazoline N-oxides and radical denitration of the adducts

[2+3] Cycloadditions between camphor-derived oxazoline N-oxide 2 and nitroalkenes 3a-f afforded stereoselectively adducts 4a-f. Radical denitration followed by acidic hydrolysis gave rise to anti-aldols 8a,b. The radical intermediate was also trapped by a suitable alkene, giving rise to a single stereoisomer.