4403-08-1

Basic information

• Product Name: 2,2',2'',2''',2'''',2'''''-(1,3,5-triazine-2,4,6-triyltrinitrilo)hexakisethanol
• Synonyms: 2,2',2'',2''',2'''',2'''''-(1,3,5-triazine-2,4,6-triyltrinitrilo)hexakisethanol;2,2',2'',2''',2'''',2'''''-(1,3,5-Triazine-2,4,6-triyltrisnitrilo)hexakisethanol;2,2',2'',2''',2'''',2'''''-[1,3,5-Triazine-2,4,6-triyltris(nitrilo)]hexakis(ethanol);2,2',2'',2''',2'''',2'''''-[1,3,5-Triazine-2,4,6-triyltris(nitrilo)]hexakisethanol;2,4,6-Tris[bis(2-hydroxyethyl)amino]-1,3,5-triazine
• CAS NO: 4403-08-1
• Molecular Formula: C₁₅H₃₀N₆O₆
• Molecular Weight: 390.4353
• EINECS: 224-539-8
• Mol File: 4403-08-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 739°Cat760mmHg
• Flash Point: 400.7°C
• Appearance: /
• Density: 1.461g/cm³
• CAS DataBase Reference: 2,2',2'',2''',2'''',2'''''-(1,3,5-triazine-2,4,6-triyltrinitrilo)hexakisethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2',2'',2''',2'''',2'''''-(1,3,5-triazine-2,4,6-triyltrinitrilo)hexakisethanol(4403-08-1)
• EPA Substance Registry System: 2,2',2'',2''',2'''',2'''''-(1,3,5-triazine-2,4,6-triyltrinitrilo)hexakisethanol(4403-08-1)

Safety Data

• Hazardous Substances Data: 4403-08-1(Hazardous Substances Data)

Usage

General Description

2,2',2'',2''',2'''',2'''''-(1,3,5-triazine-2,4,6-triyltrinitrilo)hexakisethanol, also known as hexakisethanol trinitrate (HETN), is a nitrate compound with a triazine core structure. It is a powerful and highly energetic explosive material often used in military and industrial applications. HETN is known for its high stability and low sensitivity to shock or friction, making it a valuable component in explosive formulations. It is also valued for its high energy output and relatively low susceptibility to degradation over time. However, due to its explosive nature, HETN requires careful handling and storage to ensure safety.

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 111-42-2 2,2'-iminobis[ethanol] 

Relevant articles and documents

Development and characterization of triazine based dendrimers for delivery of antitumor agent

In the present study we developed the novel kind of triazine dendrimers by utilizing differential reactivity of the cyanuric chloride (triazine trichloride) which overcome the limitations associated with the others classes of dendrimers like toxicity, low yield, high synthesis cost etc. Triazine dendrimers were synthesized by divergent method using triazine trichloride as core and diethanolamine as branching unit to avoid the use of protecting group and functional group interconversion up to third generation. These hydroxyl terminated dendrimers were characterized by FTIR, 1HNMR, 13CNMR, ES mass spectroscopy, and by Elemental analysis. The yield of pure G3 dendrimers was 63%. This novel dendrimers increases the aqueous solubility of hydrophobic drug Paclitaxel up to 0.562 mg/ml as well as showed control release behavior. Hemolytic and toxicology studies of this dendrimer in mice showed no adverse toxicity to the kidneys and the liver up to 200 mg/kg dose (i.p). Triazine being a hydrophobic compound, the core of this dendrimer is hydrophobic and supposed to easily incorporate the hydrophobic guest while presence of hydroxyl group on periphery increases its water solubility and reduces its toxicity; and thus it is useful in various fields like gene delivery, MRI contrasting agents, vaccines or as solubilization tool. Copyright

Microwave-assisted, regioselective one-pot synthesis of quinolines and bis-quinolines catalyzed by Bi(III) immobilized on triazine dendrimer stabilized magnetic nanoparticles

Fe3O4-TDSN-Bi(III) was utilized as an efficient and reusable catalyst for the regioselective one-pot synthesis of quinoline derivatives from arylamines, arylaldehydes and methyl propiolate under microwave irradiation and solvent-free conditions. Also, bis-quinolines were obtained in high yields from dialdehydes or diamines. Atom-economy, high to excellent yields, easy work-up, as well as simple catalyst recovery and reusability are the key features of this procedure.

In vitro cytotoxic activities of 2-alkyl-4,6-diheteroalkyl-1,3,5-triazines: New molecules in anticancer research

The cytotoxic activities of new 2-alkyl-4,6-dihetero-(N,O)alkyl-1,3,5- triazines toward selected tumor cell lines have been evaluated, and for the first time, the potential of 2-alkyl-4,6-dialkoxy-1,3,5-triazines has been shown.