4405-28-1

Usage

Uses

Used in Analytical Chemistry:
2-(DIMETHYLAMINO)-5-NITROBENZOIC ACID is used as a pH indicator for monitoring changes in the acidity or alkalinity of solutions. Its color change properties allow for accurate determination of pH levels, making it a valuable tool in various analytical applications.
Used in Protein Analysis:
In the field of protein analysis, 2-(DIMETHYLAMINO)-5-NITROBENZOIC ACID serves as a reagent. It aids in the identification and quantification of proteins, enabling researchers to study their structure, function, and interactions with other molecules.
Used in Microscopy and Cell Imaging:
2-(DIMETHYLAMINO)-5-NITROBENZOIC ACID is used as a fluorescent probe in microscopy and cell imaging. Its fluorescence properties allow researchers to visualize cellular structures and monitor biological processes in living cells, providing valuable insights into cell biology and disease mechanisms.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(DIMETHYLAMINO)-5-NITROBENZOIC ACID is used as a building block for the synthesis of various drugs. Its unique chemical properties make it a promising candidate for the development of new therapeutic agents, potentially leading to the discovery of novel treatments for various diseases.

InChI:InChI=1/C9H10N2O4/c1-10(2)8-4-3-6(11(14)15)5-7(8)9(12)13/h3-5H,1-2H3,(H,12,13)

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 124-40-3 dimethyl amine 
• 445-29-4 o-fluoro-benzoic acid 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 

Downstream Products

• 344303-78-2 5-amino-2-dimethylaminobenzoic acid 
• 175347-03-2 2-Dimethylamino-5-nitrobenzoyl chloride 
• 175347-11-2 2-Dimethylamino-5-nitrophenyl isocyanate 
• 175347-06-5 2-Dimethylamino-5-nitrobenzoyl azide 

Relevant academic research and scientific papers

Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects

In order to explore novel TRK and ALK dual inhibitors, a series of 2-phenylamino-4-prolylpyrimidine derivatives were designed, synthesized and evaluated for their in vitro cytotoxicity and enzymatic activities. Delightfully, most compounds were detected m

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

A series of novel N-benzylbenzamide derivatives were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, compound 20b exhibited significant antiproliferative activities with IC50 values ranging from 12 to 27 nM against several cancer cell lines, and possessed good plasma stability and satisfactory physicochemical properties. Mechanism studies demonstrated that 20b bound to the colchicine binding site and displayed potent anti-vascular activity. Notably, the corresponding disodium phosphate 20b-P exhibited an excellent safety profile with the LD50 value of 599.7 mg/kg (i.v. injection), meanwhile, it significantly inhibited tumor growth and decreased microvessel density in liver cancer cell H22 allograft mouse model without obvious toxicity. Collectively, 20b and 20b-P are novel promising anti-tubulin agents with more druggable properties and deserve to be further investigated for cancer therapy.

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Decomposition of 2-dialkylaminobenzoyl azides to yield isocyanates and 1,1 -dialky lindazol-1-ium-3-olates

Substituted benzoyl azides normally yield the correspondingly substituted isocyanates but when a dialkylated amino group is in the 2-position, in addition to the isocyanate, the 1,1-dialkylated indazol-1-ium-3-olate is produced. The ratio of the two products is very variable depending upon the substitution in the benzene ring. Largest yields of the zwitterionic products were found when there was a substituent in the 3-position regardless of whether the substituent was electron-donating or -withdrawing.