440646-09-3

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 94972-95-9 4-hydroxy-4'-benzyloxybenzophenone 
• 1028310-31-7 4-benzyloxy-4'-[(p-perfluorotolyl)oxy]benzophenone 
• 185223-78-3 (E,Z)-1-[4-(benzyloxy)phenyl]-1-(4-hydroxyphenyl)-2-phenylbut-1-ene 
• 100-39-0 benzyl bromide 
• 611-99-4 4,4'-Dihydroxybenzophenone 
• 440646-10-6 (Z)-1-[4-(benzyloxy)phenyl]-1-[4-(perfluorotolyloxy)phenyl]-2-phenylbut-1-ene 

Downstream Products

• 109517-76-2 (E)-1-[4-(benzyloxy)phenyl]-1-[4-(2-dimethylaminoethoxy)phenyl]-2-phenylbut-1-ene 
• 440646-12-8 (Z)-2-[4-[1-(4-(benzyloxy)phenyl)-2-phenyl-1-butenyl]phenoxy]acetic acid benzyl ester 
• 68047-06-3 Z-1-<4-(2-dimethylaminoethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene 
• 141777-00-6 (Z)-2-[4-[1-(p-hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]acetic acid 
• 186909-55-7 (E,Z)-1-(4-benzyloxy-phenyl)-1-[4-(5-bromopent-1-yloxy)-phenyl]-2-phenylbut-1-ene 
• 186909-76-2 (E,Z)1-(4-benzyloxyphenyl)-1-[4-(6-chlorohexyloxy)-phenyl]-2-phenylbut-1-ene 

Relevant academic research and scientific papers

Synthesis of (Z)-4-hydroxytamoxifen and (Z)-2-[4-[1-(p-hydroxyphenyl)-2-phenyl]-1-butenyl]phenoxyacetic acid

The synthesis of (Z)-4-hydroxytamoxifen and (Z)-2-[4-[1-(p-hydroxyphenyl)-2-phenyl]-1-butenyl]phenoxyacetic acid was accomplished using a McMurry reaction as the key step. The perfluorotolyl derivatives of the McMurry products enabled the separation of the minor undesirable geometrical isomer. The methodology proceeds without E,Z isomerization, employs a very mild final debenzylation step compatible with a large array of functional groups, and can be applied to the generation of a variety of 4-hydroxytamoxifen analogues.

Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents

This invention describes the new triphenylethylenes of general formula I STR1 in which n means an integer from 1 to 10, R' means a sulfur-containing organic radical, R" means a hydrogen atom, an iodine atom or a hydroxy groups, E means a hydrogen atom, G