440679-64-1

Upstream product

• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 
• 440679-63-0 C₆H₁₄N₂O₂C₈H₆O₂C₇H₄O 
• 440679-63-0 C₂₁H₂₄N₂O₅ 
• 171287-56-2 (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid 

Downstream Products

• 440679-65-2 ((S)-3-Benzyloxycarbonylamino-2-oxo-azepan-1-yloxy)-acetic acid ethyl ester 
• 210547-90-3 (S)-3-Amino-1-(tert-butyl-diphenyl-silanyloxy)-azepan-2-one 
• 440679-67-4 [(S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-azepan-1-yloxy]-acetic acid ethyl ester 
• 440679-76-5 (R)-2-[(Benzyloxy-formyl-amino)-methyl]-N-((S)-1-hydroxy-2-oxo-azepan-3-yl)-3-phenyl-propionamide 
• 440679-75-4 (R)-2-(Benzyloxyamino-methyl)-N-((S)-1-hydroxy-2-oxo-azepan-3-yl)-3-phenyl-propionamide 
• 440679-71-0 (R)-2-[(Formyl-hydroxy-amino)-methyl]-N-((S)-1-hydroxy-2-oxo-azepan-3-yl)-3-phenyl-propionamide 
• 440679-66-3 Thioacetic acid S-[(S)-1-((S)-1-hydroxy-2-oxo-azepan-3-ylcarbamoyl)-2-phenyl-ethyl] ester 
• 945496-85-5 C₅₅H₇₉N₅O₁₁ 
• 945496-86-6 C₅₅H₇₉N₅O₁₁ 
• 171287-62-0 [(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-yl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Total Synthesis of the Proposed Structure of Mycobactin J

The total synthesis of the proposed structure of mycobactin J (MJ), a metabolite of Mycobacterium tuberculosis, is presented. The highlights of the synthesis include a careful control of the Z-stereochemistry of the unsaturated long chain fatty acid, a biomimetic construction of the oxazoline building block and the carriage of an unprotected phenol throughout the synthesis.

β-Lactams in synthesis: short syntheses of cobactin analogs

Mycobactins facilitate assimilation of iron by mycobacteria. Synthetic analogs with structural variation of the cobactin component have potent anti-TB activity. A new method for the synthesis of cobactin analogs is presented. The key process involves sing

Synthesis and studies of catechol-containing mycobactin S and T analogs

The syntheses of catechol-containing mycobactin S and T analogs are described. These analogs incorporate a catechol-glycine moiety in place of the phenol-oxazoline of the naturally occurring mycobactins S and T. Studies indicated that the new siderophore

Synthesis and Biological Activity of Hydroxamic Acid-Derived Vasopeptidase Inhibitor Analogues

(Equation Presented) Syntheses of novel hydroxamic acid-derived azepinones containing pendant mercaptoacyl groups or formyl hydroxamates are described. These new analogues of therapeutically important ACE and NEP inhibitors include unprecedented changes a

An Efficient Synthesis of Cobactin T, a Key Component of the Mycobactin Class of Siderophores

Nα-Cbz-L-lysine t-butyl ester was oxidized by dimethyldioxirane to give nitrone 8c, which was converted to azopine derivative 15.Subsequent coupling and deprotection reactions afforded an efficient synthesis of cobactin T (19).