441-30-5

Basic information

• Product Name: N-(2,4-difluoro-6-nitrophenyl)acetamide
• Synonyms: acetamide, N-(2,4-difluoro-6-nitrophenyl)-; N-(2,4-Difluoro-6-nitrophenyl)acetamide
• CAS NO: 441-30-5
• Molecular Formula: C₈H₆F₂N₂O₃
• Molecular Weight: 216.1416
• Mol File: 441-30-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 358.6°C at 760 mmHg
• Flash Point: 170.7°C
• Density: 1.513g/cm³
• Vapor Pressure: 2.52E-05mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: N-(2,4-difluoro-6-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-difluoro-6-nitrophenyl)acetamide(441-30-5)
• EPA Substance Registry System: N-(2,4-difluoro-6-nitrophenyl)acetamide(441-30-5)

Safety Data

• Hazardous Substances Data: 441-30-5(Hazardous Substances Data)

Usage

General Description

N-(2,4-difluoro-6-nitrophenyl)acetamide is a chemical compound with the molecular formula C8H6F2N2O3. It is a white solid that is commonly used in the pharmaceutical and research industries as a potential anti-tuberculosis agent. It has been synthesized and studied for its potential efficacy in combating tuberculosis, a bacterial infection that primarily affects the lungs. N-(2,4-difluoro-6-nitrophenyl)acetamide is of interest due to its ability to inhibit the growth of Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis, making it a promising candidate for further drug development. Additionally, the presence of both nitro and fluoro substituents in its chemical structure makes it a valuable tool for medicinal and biological research.

Upstream product

• 399-36-0 N-(2,4-difluoro-phenyl)-acetamide 
• 364-30-7 2-amino-3,5-difluoronitrobenzene 
• 75-36-5 acetyl chloride 

Downstream Products

• 364-30-7 2-amino-3,5-difluoronitrobenzene 
• 191847-81-1 5,7-difluoro-1H-benzimidazole 3-oxide 
• 191847-66-2 N-cyanomethyl-2,4-difluoro-6-nitroaniline 
• 191847-69-5 N-(2,4-difluoro-6-nitrophenyl)glycine 
• 191847-75-3 N-(2,4-difluoro-6-nitrophenyl)glycine methyl ester 
• 1025509-55-0 N₂-ethyl-3,5-difluoro-benzene-1,2-diamine 

Relevant articles and documents

SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents

In the present study, a series of novel 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-substituted-4,6-difluoro-1H-benz o[d]imidazole derivatives are synthesized by the alkylation of 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole with substituted alkyl and aryl halides. The compounds were evaluated for their preliminary in-vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Salmonella typhosa and then were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth microdilution assay method. The antibacterial data suggested that the analogs with electronegative substituents emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antimycobacterials. Few of selected analogs are under further evaluation for secondary antitubercular screening, as they have shown better activity compared to rifampin.

HETEROCYCLYC SULFONAMIDES HAVING EDG-I ANTAGONISTIC ACTIVITY

The invention relates to chemical compounds of formula (I), (Ia) and (Ib) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man.