399-36-0

Basic information

• Product Name: 2,4-Difluoroacetanilide
• Synonyms: 2,4-Difluorophenyl acetamide;2',4'-Difluoroacetanilide 99%;2',4'-Difluoroacetanilide99%;Aminobenzene, N-acetyl-2,4-difluoro-;N-(2,4-Difluorophenyl)acetamide;2',4'-DIFLUOROACETANILIDE;2,4-DIFLUOROACETANILIDE
• CAS NO: 399-36-0
• Molecular Formula: C₈H₇F₂NO
• Molecular Weight: 171.14
• EINECS: -0
• Product Categories: Anilines, Amides & Amines;Fluorine Compounds
• Mol File: 399-36-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 122-124°C
• Boiling Point: 276.8 °C at 760 mmHg
• Flash Point: 121.2 °C
• Appearance: /
• Density: 1.307 g/cm³
• PKA: 13.02±0.70(Predicted)
• BRN: 2832300
• CAS DataBase Reference: 2,4-Difluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluoroacetanilide(399-36-0)
• EPA Substance Registry System: 2,4-Difluoroacetanilide(399-36-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 399-36-0(Hazardous Substances Data)

Usage

General Description

2,4-Difluoroacetanilide is a chemical compound that belongs to the class of acylated aromatic amines. It is formed by substituting two hydrogen atoms on the carbon backbone of acetanilide with fluorine atoms. The compound is widely used in the production of pharmaceuticals, agrochemicals, and chemical research. It is known for its ability to inhibit the activity of certain enzymes and proteins, making it a valuable tool in the study of biological processes. 2,4-Difluoroacetanilide also has applications in the development of new materials and compounds, showcasing its versatility and importance in various industries.

Upstream product

• 103-84-4 Acetanilid 
• 446-35-5 2,4-Difluoronitrobenzene 
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• 367-25-9 2,4-difluorophenylamine 
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Downstream Products

• 325-66-6 2,4-difluoro-N-phenylbenzenamine 
• 364-30-7 2-amino-3,5-difluoronitrobenzene 
• 441-30-5 2,4-difluoro-6-nitroacetanilide 
• 319-88-0 1,3,5-trichlorotrifluorobenzene 
• 2369-29-1 3,5-difluoro-1,2-phenylenediamine 
• 439-17-8 5,7-difluoro-2,3-diphenyl-quinoxaline 
• 372-39-4 3,5-difluoroaniline 
• 2367-76-2 2,4,6-trifluorobromobenzene 
• 1435-43-4 1-chloro-3,5-difluorobenzene 
• 315-14-0 1,3,5-trifluoro-2-nitrobenzene 
• 2106-40-3 2-chloro-1,3,5-trifluorobenzene 
• 2265-94-3 1,3-difluoro-5-nitrobenzene 
• 2368-49-2 1,3,5-tribromo-2,4,6-trifluoro-benzene 
• 2368-53-8 1,3-dichloro-2,4,6-trifluorobenzene 

Relevant articles and documents

Electrochemical formation of: N, N ′-diarylhydrazines by dehydrogenative N-N homocoupling reaction

Hydrazines represent a class of compounds of high interest due to their applicability as versatile starting materials in many important transformations. Herein, we report a synthetic approach to hydrazine derivatives using commercially available anilines and an anodic dehydrogenative N-N coupling reaction as the key step.

Selective Csp2-Csp bond cleavage: The nitrogenation of alkynes to amides

Breakthrough: A novel catalyzed direct highly selective C sp 2-C sp bond functionalization of alkynes to amides has been developed. Nitrogenation is achieved by the highly selective C sp 2-Csp bond cleavage of aryl-substituted alkynes. The oxidant-free and mild conditions and wide substrate scope make this method very practical. Copyright

SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents

In the present study, a series of novel 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-substituted-4,6-difluoro-1H-benz o[d]imidazole derivatives are synthesized by the alkylation of 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole with substituted alkyl and aryl halides. The compounds were evaluated for their preliminary in-vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Salmonella typhosa and then were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth microdilution assay method. The antibacterial data suggested that the analogs with electronegative substituents emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antimycobacterials. Few of selected analogs are under further evaluation for secondary antitubercular screening, as they have shown better activity compared to rifampin.