441317-46-0

Upstream product

• 1026005-07-1 4-(tert-butyl-diphenyl-silanyloxy)-3-methanesulfonyloxymethyl-butyric acid methyl ester 
• 328386-20-5 (+/-)-3-(tert-butyldiphenylsilyloxymethyl)-4-hydroxymethylbutyric acid methyl ester 
• 328386-16-9 (+/-)-4-(tert-butyldiphenylsilyloxymethyl)-4H,5H-dihydrofuran-2-one 
• 212776-53-9 4-(tert-Butyl-diphenyl-silanyloxymethyl)-5H-furan-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 80904-75-2 4-hydroxymethyl-5H-furan-2-one 

Downstream Products

• 381211-46-7 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-2-yl]-1H-pyrimidine-2,4-dione 
• 381211-48-9 9-[4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-2-yl]-6-chloro-9H-purine 
• 381211-47-8 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Structure-activity relationships of apio nucleosides as potential antiviral agents

Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.