441348-16-9

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 757181-19-4 (S)-2-Amino-3-[3'-(3-propyl-ureido)-biphenyl-4-yloxy]-propionic acid methyl ester 
• 441348-13-6 Methyl O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate Hydro-Chloride 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 441348-02-3 (S)-3-[3'-(3-Propyl-ureido)-biphenyl-4-yloxy]-2-(trityl-amino)-propionic acid methyl ester 
• 441348-00-1 methyl O-(3'-amino-1,1'-biphenyl-4-yl)-N-triphenylmethyl-L-serinate 
• 558482-75-0 methyl (2S)-3-(4-bromophenoxy)-2-(tritylamino)propanoate 
• 106-41-2 4-bromo-phenol 

Relevant academic research and scientific papers

Biphenyls as potent vitronectin receptor antagonists. Part 2: Biphenylalanine ureas

Vitronectin receptor (αVβ3) antagonism has been implicated in a variety of disease states, like restenosis, osteoporosis and cancer. In this work, we present the development of a novel class of biphenyl vitronectin receptor antagonists. Identified from a focused combinatorial library based on para-bromo phenylalanine, these compounds show nanomolar affinity to the vitronectin receptor and display unprecedented SAR. Their binding mode can be rationalized by computational docking studies using the X-ray structure of αVβ3.

Phenylserine derivatives as integrin antagonists

The present invention relates to new phenylserine derivatives as integrin antagonists with a broad spectrum of action having, inter alia, antiosteoporotic, antirestenotic, anticarcinogenic and antiatherosclerotic activity. The present invention moreover r