441759-67-7Relevant academic research and scientific papers
Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases
Beseda, Igor,Czollner, Laszlo,Shah, Priti S.,Khunt, Rupesh,Gaware, Rawindra,Kosma, Paul,Stanetty, Christian,Ruiz-Ruiz, Maria Carmen del,Amer, Hassan,Mereiter, Kurt,Cunha, Thierry Da,Odermatt, Alex,Classen-Houben, Dirk,Jordis, Ulrich
experimental part, p. 433 - 454 (2010/03/30)
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11β-hydroxysteroid dehydrogenase (11β-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.
Synthesis and hemolytic properties of lactosides of glycyrrhetic acid derivatives
Ullah, Nisar,Seebacher, Werner,Haslinger, Ernst,Jurenitsch, Johann,Rauchensteiner, Katharina,Weis, Robert
, p. 139 - 150 (2007/10/03)
The partial synthesis of lactosides of glycyrrhetic acid, its 11-deoxo and 18α-derivatives, and their methyl esters is described. The influence of the aglycon structure on the hemolytic properties of the title compounds is discussed and compared with those of oleanolic acid derivatives. Furthermore, we describe an optimized preparation of 18α-glycyrrhetic acid.
