441774-09-0

Basic information

• Product Name: 1,4-Piperidinedicarboxylic acid, 4-(2-propenyl)-, 1-(1,1-dimethylethyl) 4-methyl ester
• Synonyms: 1,4-Piperidinedicarboxylic acid, 4-(2-propenyl)-, 1-(1,1-dimethylethyl) 4-methyl ester;1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-methyl ester;4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-methyl ester;4-(2-Propen-1-yl)-1,4-piperidinedicarboxylic acid 1-tert-butyl 4-methyl ester;4-(2-Propenyl)-1,4-piperidinedicarboxylicacid-1-(1,1-dimethylethyl)4-methylester;1-tert-butyl 4-Methyl 4-allylpiperidine-1,4-dicarboxylate;N-Boc-4-(1-propylene) nipecotic acid Methyl ester;1-tert-butyl 4-Methyl 4-allylpiperidin -1,4-dicarboxylate
• CAS NO: 441774-09-0
• Molecular Formula: C₁₅H₂₅NO₄
• Molecular Weight: 283.36
• Product Categories: piperidine
• Mol File: 441774-09-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 342.4 °C at 760 mmHg
• Flash Point: 160.9 °C
• Appearance: /
• Density: 1.049
• Refractive Index: 1.474
• PKA: -2.35±0.40(Predicted)
• CAS DataBase Reference: 1,4-Piperidinedicarboxylic acid, 4-(2-propenyl)-, 1-(1,1-dimethylethyl) 4-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Piperidinedicarboxylic acid, 4-(2-propenyl)-, 1-(1,1-dimethylethyl) 4-methyl ester(441774-09-0)
• EPA Substance Registry System: 1,4-Piperidinedicarboxylic acid, 4-(2-propenyl)-, 1-(1,1-dimethylethyl) 4-methyl ester(441774-09-0)

Safety Data

• Hazardous Substances Data: 441774-09-0(Hazardous Substances Data)

Usage

General Description

1,4-Piperidinedicarboxylic acid, 4-(2-propenyl)-, 1-(1,1-dimethylethyl) 4-methyl ester, also known as Boc-4-methyl-DL-proline, is a chemical compound that is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and specialty chemicals. It is a derivative of proline, an amino acid, and is often used in the production of peptide-based drugs and biologically active molecules. 1,4-Piperidinedicarboxylic acid, 4-(2-propenyl)-, 1-(1,1-dimethylethyl) 4-methyl ester is known for its ability to modify the activity and stability of bioactive molecules, making it a valuable tool in drug discovery and development. Additionally, it is also utilized in the preparation of peptide-based materials and biomaterials for various applications in the field of biomedical engineering.

InChI:InChI=1/C15H25NO4/c1-6-7-15(12(17)19-5)8-10-16(11-9-15)13(18)20-14(2,3)4/h6H,1,7-11H2,2-5H3

Upstream product

• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 106-95-6 allyl bromide 

Downstream Products

• 1422558-61-9 C₂₁H₂₈F₃NO₂ 
• 693824-61-2 1-(tert-butyl) 4-methyl 4-(2-oxoethyl)piperidine-1,4-dicarboxylate 
• 441774-14-7 4-methoxycarbonylmethyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 441774-11-4 4-carboxymethyl-4-(4-hydroxy-phenylsulfanylmethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 441774-12-5 4-(4-hydroxy-phenylsulfanylmethyl)-4-methoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 203662-19-5 tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 236406-37-4 tert-butyl 4-(hydroxymethyl)-4-(prop-2-en-1-yl)piperidine-1-carboxylate 
• 426842-70-8 4-allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid 

Relevant articles and documents

Iodoarene-Catalyzed Oxyamination of Unactivated Alkenes to Synthesize 5-Imino-2-Tetrahydrofuranyl Methanamine Derivatives

Reported here is the room-temperature metal-free iodoarene-catalyzed oxyamination of unactivated alkenes. In this process, the alkenes are difunctionalized by the oxygen atom of the amide group and the nitrogen in an exogenous HNTs2 molecule. This mild and open-air reaction provided an efficient synthesis to N-bistosyl-substituted 5-imino-2-tetrahydrofuranyl methanamine derivatives, which are important motifs in drug development and biological studies. Mechanistic study based on experiments and density functional theory calculations showed that this transformation proceeds via activation of the substrate alkene by an in situ generated cationic iodonium(III) intermediate, which is subsequently attacked by an oxygen atom (instead of nitrogen) of amides to form a five-membered ring intermediate. Finally, this intermediate undergoes an SN2 reaction by NTs2 as the nucleophile to give the oxygen and nitrogen difunctionalized 5-imino-2-tetrahydrofuranyl methanamine product. An asymmetric variant of the present alkene oxyamination using chiral iodoarenes as catalysts also gave promising results for some of the substrates.

RAS INHIBITORS

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

CGRP RECEPTOR ANTAGONISTS

The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.