426842-70-8

Basic information

• Product Name: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester
• Synonyms: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester;1-Boc-4-allyl-4-piperidinecarboxylic Acid;1-[(tert-butoxy)carbonyl]-4-(prop-2-en-1-yl)piperidine-4-carboxylic acid;4-Allyl-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid;1-Boc-4-(2-propenyl)-4-piperidinecarboxylic acid;4-Allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid
• CAS NO: 426842-70-8
• Molecular Formula: C₁₄H₂₃NO₄
• Molecular Weight: 269.34
• Product Categories: piperidine
• Mol File: 426842-70-8.mol

Chemical Properties

• Boiling Point: 380.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.101±0.06 g/cm3(Predicted)
• PKA: 4.55±0.20(Predicted)
• CAS DataBase Reference: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester(426842-70-8)
• EPA Substance Registry System: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester(426842-70-8)

Safety Data

• Hazardous Substances Data: 426842-70-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester is used as a key component in the formulation of drugs for the treatment of moderate to severe Alzheimer's disease. It functions by blocking the receptor for the neurotransmitter glutamate, which is crucial for improving cognitive function and slowing the progression of the disease.
Additionally, due to its neuroprotective and anti-inflammatory properties, 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester is used as a subject of research for potential applications in the broader field of neurodegenerative diseases. Its multifaceted properties make it a molecule of interest for further exploration and development in pharmaceutical research and drug discovery.

Upstream product

• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 676341-47-2 allyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate 
• 146603-99-8 1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 441774-09-0 1-(tert-butyl) 4-methyl 4-allylpiperidine-1,4-dicarboxylate 

Downstream Products

• 951743-89-8 4-allyl-4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine 
• 951745-40-7 1-tert-butoxycarbonyl-4-allyl-4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)piperidine 
• 951743-90-1 4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine 
• 1192190-10-5 3-[4-allyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate 
• 1192189-26-6 4-allyl-N-(3-chlorophenyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 
• 1192189-28-8 4-allyl-N-(3-chlorophenyl)piperidine-4-carboxamide hydrochloride 
• 1192189-27-7 tert-butyl 4-allyl-4-(3-chlorophenylcarbamoyl)piperidine-1-carboxylate 
• 951745-39-4 (1,2-bis(4-methoxyphenyl)-2-oxoethyl) 1-tert-butoxycarbonyl-4-allyl-4-piperidinecarboxylate 

Relevant articles and documents

Iodoarene-Catalyzed Oxyamination of Unactivated Alkenes to Synthesize 5-Imino-2-Tetrahydrofuranyl Methanamine Derivatives

Reported here is the room-temperature metal-free iodoarene-catalyzed oxyamination of unactivated alkenes. In this process, the alkenes are difunctionalized by the oxygen atom of the amide group and the nitrogen in an exogenous HNTs2 molecule. This mild and open-air reaction provided an efficient synthesis to N-bistosyl-substituted 5-imino-2-tetrahydrofuranyl methanamine derivatives, which are important motifs in drug development and biological studies. Mechanistic study based on experiments and density functional theory calculations showed that this transformation proceeds via activation of the substrate alkene by an in situ generated cationic iodonium(III) intermediate, which is subsequently attacked by an oxygen atom (instead of nitrogen) of amides to form a five-membered ring intermediate. Finally, this intermediate undergoes an SN2 reaction by NTs2 as the nucleophile to give the oxygen and nitrogen difunctionalized 5-imino-2-tetrahydrofuranyl methanamine product. An asymmetric variant of the present alkene oxyamination using chiral iodoarenes as catalysts also gave promising results for some of the substrates.

Novel trinitrogen-containing triheterocycles via the intramolecular nitrile oxide cycloaddition reaction

The intramolecular nitrile oxide cycloaddition (INOC) reaction is applied to the synthesis of novel isoxazolooxazepinoindazole, benzoisoxazolodiazepinoindazolone, and spiro[isoxazoloazepine]piperidine heterocycles. Each of these targets incorporates a uni

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

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Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists

4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius rearrangement as a key step. The alkylation of isonipecotate could introduce various substituents at the 4-position of the piperidine ring. With this key building block, we are able to efficiently synthesize piperazino-piperidine based CCR5 antagonist in a highly convergent manner free of using toxic reagents such as diethylaluminum cyanide. The concise synthesis of a potent bioavailable CCR5 antagonist as HIV-1 entry inhibitor, Sch-350634 (1) was accomplished in excellent yield using N′-Boc-4-methyl-4-aminopiperidine 5a as a smart building block. The new methodology provides a facile and practical access to the piperazino-piperidine amide analogs as HIV-1 entry inhibitors.

Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them

Heterocyclylalkylpiperidine derivatives of general formula (I) in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.