441790-65-4Relevant academic research and scientific papers
Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors1-4 V. A series of new derivatives containing a spiro[imidazo[1,2-a]pyrazine-2(3H),4′-piperidin]-5(1H)-one scaffold
Saitoh, Fumihiko,Mukaihira, Takafumi,Nishida, Hidemitsu,Satoh, Tsutomu,Okano, Akihiro,Yumiya, Yasunobu,Ohkouchi, Munetaka,Johka, Rumi,Matsusue, Tomokazu,Shiromizu, Ikuya,Hosaka, Yoshitaka,Matsumoto, Miwa,Ohnishi, Shuhei
, p. 1535 - 1544 (2007/10/03)
We have already reported unique compounds containing a N,O-spiro acetal structure as an orally active factor Xa (FXa) inhibitor. This time, we described a N,N-spiro acetal structure as an analogue of the N,O-spiro acetal structure for an orally active FXa
