441790-48-3

Upstream product

• 930-37-0 glycidyl methyl ether 
• 501-53-1 benzyl chloroformate 
• 459-73-4 GlyOEt*HCl 
• 318986-48-0 ethyl 2-(2-hydroxy-3-methoxypropylamino)acetate 

Downstream Products

• 441790-64-3 tetrahydro-8a-(methoxymethyl)-5-oxo-1'-(phenylmethyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester 
• 441790-66-5 tetrahydro-8a-(methoxymethyl)-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester 
• 441790-68-7 tetrahydro-8a-(methoxymethyl)-1-methyl-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester 
• 441790-65-4 C₂₀H₂₈N₄O₄ 
• 441790-49-4 N-(3-methoxy-2-oxopropyl)-N-[(phenylmethoxy)carbonyl]glycine ethyl ester 

Relevant academic research and scientific papers

Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors1-4 V. A series of new derivatives containing a spiro[imidazo[1,2-a]pyrazine-2(3H),4′-piperidin]-5(1H)-one scaffold

We have already reported unique compounds containing a N,O-spiro acetal structure as an orally active factor Xa (FXa) inhibitor. This time, we described a N,N-spiro acetal structure as an analogue of the N,O-spiro acetal structure for an orally active FXa

TRICYCLIC COMPOUND HAVING SPIRO UNION

This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.