442-72-8

Basic information

• Product Name: Benzamide, 4-fluoro-N-1-naphthalenyl-
• Synonyms: 4-Fluoro-N-naphthalen-1-yl-benzamide;4-fluoro-benzoic acid-[1]naphthylamide;4-Fluor-benzoesaeure-[1]naphthylamid
• CAS NO: 442-72-8
• Molecular Formula: C17H12FNO
• Molecular Weight: 265.28200
• Mol File: 442-72-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 166 - 168 °C
• CAS DataBase Reference: Benzamide, 4-fluoro-N-1-naphthalenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-fluoro-N-1-naphthalenyl-(442-72-8)
• EPA Substance Registry System: Benzamide, 4-fluoro-N-1-naphthalenyl-(442-72-8)

Safety Data

• Hazardous Substances Data: 442-72-8(Hazardous Substances Data)

Upstream product

• 134-32-7 1-amino-naphthalene 
• 403-43-0 4-fluorobenzoyl chloride 
• 824-75-9 p-fluorobenzamide 
• 90-13-1 1-Chloronaphthalene 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 456-22-4 4-Fluorobenzoic acid 
• 90-14-2 1-Iodonaphthalene 
• 140-75-0 para-fluorobenzylamine 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1346684-67-0 6-fluoro-2,3-diphenylisoquinolin-1(2H)-one 

Relevant articles and documents

Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides

This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd0/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst.

The synthesis of N-arylated amides via copper(II) triflate-catalyzed direct oxygenation and N-arylation of benzylamines with aryl iodides

An efficient approach for the synthesis of N-arylated amides by copper(II) triflate-catalyzed direct oxygenation and N-arylation reaction of benzylamines with aryl iodides is reported. Various benzylamines and aryl iodides can participate in the reaction, providing a series of N-arylated amides in moderate to good yields.