442124-65-4

Basic information

• Product Name: 1-(4-METHOXY-BENZENESULFONYL)-PIPERIDIN-4-YLAMINE HCL
• Synonyms: 1-(4-METHOXY-BENZENESULFONYL)-PIPERIDIN-4-YLAMINE HCL;1-[(4-METHOXYPHENYL)SULFONYL]PIPERIDIN-4-AMINE HYDROCHLORIDE;1-(4-Methoxybenzenesulfonyl)piperidin-4-ylamine hydrochloride
• CAS NO: 442124-65-4
• Molecular Formula: C12H19ClN2O3S
• Molecular Weight: 306.80886
• Mol File: 442124-65-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 450 °C at 760 mmHg
• Flash Point: 225.9 °C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 2.13E-07mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 1-(4-METHOXY-BENZENESULFONYL)-PIPERIDIN-4-YLAMINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-BENZENESULFONYL)-PIPERIDIN-4-YLAMINE HCL(442124-65-4)
• EPA Substance Registry System: 1-(4-METHOXY-BENZENESULFONYL)-PIPERIDIN-4-YLAMINE HCL(442124-65-4)

Safety Data

• Hazardous Substances Data: 442124-65-4(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxy-benzenesulfonyl)-piperidin-4-ylamine HCL is a chemical compound that belongs to the class of piperidines and sulfonamides. It is commonly used as a building block in the synthesis of various pharmaceuticals and biologically active molecules. The compound has a piperidine ring with a sulfonamide group attached to it, and a methoxybenzene substituent at the 1-position of the piperidine ring. The HCL salt form of the compound is typically used for better solubility and stability. It may have potential applications in the treatment of various diseases, as well as in the field of medicinal chemistry for drug discovery and development.

InChI:InChI=1/C12H18N2O3S/c1-17-11-2-4-12(5-3-11)18(15,16)14-8-6-10(13)7-9-14/h2-5,10H,6-9,13H2,1H3

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Relevant articles and documents

Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents

A series of ethacrynic acid (2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding 6a and 6c, showed anti-proliferative activity with IC50s in the micromolar range (less than 4 uM). Three derivatives 6b, 7b and 7e were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRC5 as a normal cell line. These compounds displayed IC50 values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker's best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8.