442129-00-2

Upstream product

• 616-34-2 methoxycarbonylmethylamine 
• 442128-96-3 (1S)-3-(4-benzyloxyphenyl)-2-[(N)-tert-butoxycarbonyl]methylaminopropanal 
• 442128-91-8 1,1-dimethylethyl N-[(1S)-2-hydroxy-1-{[4-(phenylmethoxy)phenyl]methyl}ethyl]-N-methylcarbamate 
• 442128-78-1 methyl (2S)-3-(4-benzyloxyphenyl)-2-ethoxycarbonylaminopropionate 
• 442128-85-0 (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine 
• 215596-38-6 (S)-3-(4-hydroxyphenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester 
• 3417-91-2 L-tyrosine methyl ester HCl 

Downstream Products

• 442129-04-6 methyl N-[(2S)-3-(4-benzyloxyphenyl)-2-methylaminopropyl]aminoacetate 
• 442129-12-6 (6S)-6-(4-hydroxybenzyl)-1-methylpiperazin-2-one 
• 442129-08-0 (6S)-6-(4-benzyloxybenzyl)-1-methylpiperazin-2-one 

Relevant academic research and scientific papers

A formal synthesis of a muscarinic M1 receptor antagonist, (-)-TAN1251A

An aromatic oxidation reaction of a secondary amine, prepared from L-tyrosine and glycine, with hypervalent iodine reagent gave a spirocyclic product, which was further converted into the key intermediate for the synthesis of (-)-TAN1251A.

Facile synthesis of enantiopure (-)-TAN1251A

Formal total synthesis of enantiopure (-)-TAN1251A, a muscarinic M1 receptor antagonist, was achieved via a spirocyclic carbon-nitrogen bond formation by the use of aromatic oxidation with bis(acetoxy)iodobenzene as a key step.