442134-70-5

Basic information

• Product Name: 6-bromo-N-(4-fluoro-phenyl)-nicotinamide
• Synonyms: 6-bromo-N-(4-fluoro-phenyl)-nicotinamide
• CAS NO: 442134-70-5
• Molecular Weight: 295.111
• Mol File: 442134-70-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-bromo-N-(4-fluoro-phenyl)-nicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-N-(4-fluoro-phenyl)-nicotinamide(442134-70-5)
• EPA Substance Registry System: 6-bromo-N-(4-fluoro-phenyl)-nicotinamide(442134-70-5)

Safety Data

• Hazardous Substances Data: 442134-70-5(Hazardous Substances Data)

Upstream product

• 740841-42-3 6-bromonicotinoyl chloride 
• 371-40-4 4-fluoroaniline 
• 6311-35-9 6-bromonicotinic acid 

Downstream Products

• 470465-86-2 [5-(4-fluoro-phenylcarbamoyl)-pyridin-2-yloxy]-acetic acid methyl ester 
• 1240495-82-2 6-(benzyloxy)-N-(4-fluorophenyl)nicotinamide 
• 1240496-05-2 N-(4-fluorophenyl)-6-(2-iodo-benzyloxy)-nicotinamide 
• 1240495-81-1 C₁₉H₁₆BFN₂O₄ 
• 1240496-06-3 C₂₅H₂₆BFN₂O₄ 
• 1360598-89-5 SX-632 
• 1360599-06-9 C₂₆H₂₉BFN₃O₃ 
• 1360598-88-4 SX-629 
• 1360598-87-3 SX-628 
• 1360598-86-2 SX-627 
• 1360598-96-4 C₂₆H₂₉BFN₃O₃ 
• 1360598-93-1 C₂₀H₁₇BrFN₃O 
• 1360598-94-2 C₁₉H₁₅BrFN₃O 
• 1360599-01-4 C₂₀H₁₇BrFN₃O 

Relevant articles and documents

Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability

Abstract The chemokine receptors CXCR1 and CXCR2 are important pharmaceutical targets due to their key roles in inflammatory diseases and cancer progression. We have previously identified 2-[5-(4-fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanylmethyl]-phenylboronic acid (SX-517) and 6-(2-boronic acid-5-trifluoromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide (SX-576) as potent non-competitive boronic acid-containing CXCR1/2 antagonists. Herein we report the synthesis and evaluation of aminopyridine and aminopyrimidine analogs of SX-517 and SX-576, identifying (2-{(benzyl)[(5-boronic acid-2-pyridyl)methyl]amino}-5-pyrimidinyl)(4-fluorophenylamino)formaldehyde as a potent chemokine antagonist with improved aqueous solubility and oral bioavailability.

Aminopyridine- and Aminopyrimidinecarboxamides as CXCR2 Modulators

There is disclosed aminopyridine-and aminopyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include aminopyridine- and aminopyrimidinecarboxamides compounds. More specifically, ther

Pharmaceutical uses and synthesis of nicotinamides

A compound of the formula and pharmaceutically acceptable salts thereof, wherein R1is selected from (R3)C(═O)—N(R4)— and (R3)(R4)N—C(═O)—; R2is selected from —OR5and —N(R5)(R6); n is 0, 1, 2 or 3; X is selected from oxygen and sulfur; and R3, R4, R5and R6are independently selected from hydrogen, alkyl, heteroalkyl, aryl, aryl(akylene), heteroaryl, heteroaryl(alkylene), carbocycle, carbocycle(alkylene), heterocycle, and heterocycle(alkylene); as well as pharmaceutical compositions containing said compound. The compounds and compositions are useful in, for example, the treatment of inflammatory events in an animal subject.