470465-86-2Relevant academic research and scientific papers
Nicotinanilides as inhibitors of neutrophil chemotaxis
Cutshall, Neil S.,Kucera, Kristin A.,Ursino, Rocky,Latham, John,Ihle, Nathan C.
, p. 1517 - 1520 (2002)
A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-α-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic
Pharmaceutical uses and synthesis of nicotinamides
-
Page/Page column 32, (2010/02/08)
A compound of the formula and pharmaceutically acceptable salts thereof, wherein R1is selected from (R3)C(═O)—N(R4)— and (R3)(R4)N—C(═O)—; R2is selected from —OR5and —N(R5)(R6); n is 0, 1, 2 or 3; X is selected from oxygen and sulfur; and R3, R4, R5and R6are independently selected from hydrogen, alkyl, heteroalkyl, aryl, aryl(akylene), heteroaryl, heteroaryl(alkylene), carbocycle, carbocycle(alkylene), heterocycle, and heterocycle(alkylene); as well as pharmaceutical compositions containing said compound. The compounds and compositions are useful in, for example, the treatment of inflammatory events in an animal subject.
