4422-93-9

Upstream product

• 123-00-2 4-(3-Aminopropyl)morpholine 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Highly efficient preparation of amides from aminium carboxylates using N-(p-toluenesulfonyl) imidazole

Treatment of aminium carboxylates with N-(p-toluenesulfonyl)imidazole in the presence of triethylamine in DMF at 100 °C afforded the corresponding amides in good to excellent yields. N-(p-Toluenesulfonyl)imidazole proved to be a highly efficient coupling reagent for the preparation of numerous structurally diverse primary, secondary and tertiary amides.

A mild chemospecific reductive dehalogenation of ethylaminobenzamides with lithium aluminum hydride

A mild reduction of ortho-fluoro benzamides was discovered using LAH. The reaction proceeds cleanly and in moderate yields. The scope of the reaction is explored and a mechanism is proposed. A two carbon spacer between the amide and a 3°amine is optimal for this chelation controlled reaction.