442549-49-7

Upstream product

• 32338-02-6 2-bromo-4-methoxyaniline 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 919794-72-2 8-[ethyl-(1-ethyl-pyrrolidin-3-yl)-amino]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 919794-70-0 8-(3-dimethylamino-pyrrolidin-1-yl)-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 919794-68-6 8-(3-dimethylamino-pyrrolidin-1-yl)-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 442549-57-7 6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide 
• 919794-74-4 6-methoxy-8-[methyl-(1-methyl-pyrrolidin-3-yl)-amino]-4-(2-trimethylsilanyl-ethoxymethoxy)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 919794-63-1 8-[(3-dimethylamino-propyl)-methyl-amino]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 919794-65-3 8-[(2-dimethylamino-ethyl)-methyl-amino]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 442549-56-6 8-bromo-6-methoxy-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide 
• 442549-59-9 8-bromo-4-dimethylamino-6-methoxy-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 919794-77-7 8-bromo-4-methylamino-6-methoxyquinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide 
• 442549-55-5 8-bromo-6-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 442549-58-8 8-bromo-4-chloro-6-methoxy-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 

Relevant academic research and scientific papers

Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: A late-stage diversification approach to potent 5HT1B antagonists

Multiparallel amenable syntheses of 6-methoxy-8-amino-4-oxo-1,4-dihydroquinoline-2-carboxylic acid-(4-morpholin-4-yl-phenyl)amides (I) and 4-amino-6-methoxy-8-(4-methyl-piperazin-1-yl)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides (II) which facilitate late-stage diversification at the 8-position of (I) and at the 4- and 8-positions of (II) are described. The resulting novel series were determined to contain potent 5HT1B antagonists. Preliminary SAR data are presented.