919794-72-2

Upstream product

• 32338-02-6 2-bromo-4-methoxyaniline 
• 442549-55-5 8-bromo-6-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide 
• 442549-49-7 2-(2-bromo-4-methoxyphenylamino)but-2-enedioic acid dimethyl ester 
• 442549-50-0 8-bromo-6-methoxy-4-oxo-1,4-dihydroquinoline-2-carboxylic acid methyl ester 
• 442549-54-4 8-bromo-6-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid 
• 108963-17-3 1-ethyl-3-(ethylamino)pyrrolidine 
• 442549-56-6 8-bromo-6-methoxy-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide 

Relevant academic research and scientific papers

Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: A late-stage diversification approach to potent 5HT1B antagonists

Multiparallel amenable syntheses of 6-methoxy-8-amino-4-oxo-1,4-dihydroquinoline-2-carboxylic acid-(4-morpholin-4-yl-phenyl)amides (I) and 4-amino-6-methoxy-8-(4-methyl-piperazin-1-yl)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides (II) which facilitate late-stage diversification at the 8-position of (I) and at the 4- and 8-positions of (II) are described. The resulting novel series were determined to contain potent 5HT1B antagonists. Preliminary SAR data are presented.