4426-48-6

Basic information

• Product Name: 1,2-DIAMINOBUTANE
• Synonyms: 1,2-DIAMINOBUTANE;(±)-1,2-Butanediamine;(R,S)-1,2-Butanediamine;Butane-1,2-diamine
• CAS NO: 4426-48-6
• Molecular Formula: C4H12N2
• Molecular Weight: 88.15
• Mol File: 4426-48-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 138.4°Cat760mmHg
• Flash Point: 36.3°C
• Appearance: /
• Density: 0.861g/cm³
• Vapor Pressure: 6.74mmHg at 25°C
• Refractive Index: 1.452
• PKA: pK1: 6.399(+2);pK2: 9.388(+1) (25°C)
• CAS DataBase Reference: 1,2-DIAMINOBUTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIAMINOBUTANE(4426-48-6)
• EPA Substance Registry System: 1,2-DIAMINOBUTANE(4426-48-6)

Safety Data

• Hazardous Substances Data: 4426-48-6(Hazardous Substances Data)

Usage

General Description

1,2-Diaminobutane, also known as putrescine, is a chemical compound with the molecular formula C4H12N2. It is a colorless, viscous liquid with a fishy odor. 1,2-Diaminobutane is commonly used in the production of plastics, resins, and pharmaceuticals. It is also a precursor to the synthesis of various compounds, including polyamides and polyurethanes. Additionally, 1,2-Diaminobutane is found naturally in certain foods and is a byproduct of the decomposition of organic matter. In the human body, putrescine is involved in the synthesis of polyamines, which have crucial roles in cell growth and differentiation.

InChI:InChI=1/C4H12N2/c1-2-4(6)3-5/h4H,2-3,5-6H2,1H3

Upstream product

• 40651-89-6 2-aminobutyronitrile 
• 533-98-2 1,2-dibromobutane 
• 29585-61-3 1,2-dinitro-butane 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 53726-14-0 (S)-2-amino-butanamide hydrochloride 
• 106-98-9 1-butylene 
• 93554-80-4 2-aminobutyronitrile hydrochloride 
• 118641-80-8 ethyl-ethanediyl diisocyanate 

Downstream Products

• 193959-54-5 N-[2-(6-Ethyl-3-oxo-3,4,5,6-tetrahydro-pyrazin-2-yl)-phenyl]-acetamide 
• 168092-04-4 4-ethylimidazolidine-2-one 

Relevant articles and documents

Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

Cardioprotective activity of dexrazoxane (ICRF-187), the only clinically approved drug against anthracycline-induced cardiotoxicity, has traditionally been attributed to its iron-chelating metabolite. However, recent experimental evidence suggested that the inhibition and/or depletion of topoisomerase IIβ (TOP2B) by dexrazoxane could be cardioprotective. Hence, we evaluated a series of dexrazoxane analogues and found that their cardioprotective activity strongly correlated with their interaction with TOP2B in cardiomyocytes, but was independent of their iron chelation ability. Very tight structure-activity relationships were demonstrated on stereoisomeric forms of 4,4′-(butane-2,3-diyl)bis(piperazine-2,6-dione). In contrast to its rac-form 12, meso-derivative 11 (ICRF-193) showed a favorable binding mode to topoisomerase II in silico, inhibited and depleted TOP2B in cardiomyocytes more efficiently than dexrazoxane, and showed the highest cardioprotective efficiency. Importantly, the observed ICRF-193 cardioprotection did not interfere with the antiproliferative activity of anthracycline. Hence, this study identifies ICRF-193 as the new lead compound in the development of efficient cardioprotective agents.

Lipophilic polyamines useful for treating hypercholesterolemia

This invention relates to novel lipophilic polyamines of formula I, the method of using these compounds to treat hypercholesterolemia, and intermediates thereto.