4426-48-6

Usage

Uses

Used in Chemical Synthesis:
1,2-Diaminobutane is used as a precursor in the synthesis of various compounds, such as polyamides and polyurethanes, for its ability to form stable amide and urea linkages.
Used in Plastics and Resin Production:
1,2-Diaminobutane is used as a monomer in the production of plastics and resins, contributing to their structural integrity and performance characteristics.
Used in Pharmaceutical Industry:
1,2-Diaminobutane is used as an intermediate in the synthesis of pharmaceuticals, leveraging its reactivity and ability to form complex molecular structures.
Used in Food Industry:
Although not a direct additive, 1,2-Diaminobutane is found naturally in certain foods and is a byproduct of the decomposition of organic matter, indicating its natural presence in the food chain.
Used in Biomedical Research:
In the human body, putrescine is involved in the synthesis of polyamines, which have crucial roles in cell growth and differentiation. This makes 1,2-Diaminobutane an important compound in biomedical research for understanding cellular processes and developing therapeutic interventions.

InChI:InChI=1/C4H12N2/c1-2-4(6)3-5/h4H,2-3,5-6H2,1H3

Upstream product

• 40651-89-6 2-aminobutyronitrile 
• 118641-80-8 ethyl-ethanediyl diisocyanate 
• 29585-61-3 1,2-dinitro-butane 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 53726-14-0 (S)-2-amino-butanamide hydrochloride 
• 106-98-9 1-butylene 
• 93554-80-4 2-aminobutyronitrile hydrochloride 
• 533-98-2 1,2-dibromobutane 

Downstream Products

• 193959-54-5 N-[2-(6-Ethyl-3-oxo-3,4,5,6-tetrahydro-pyrazin-2-yl)-phenyl]-acetamide 
• 168092-04-4 4-ethylimidazolidine-2-one 

Relevant academic research and scientific papers

Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

Cardioprotective activity of dexrazoxane (ICRF-187), the only clinically approved drug against anthracycline-induced cardiotoxicity, has traditionally been attributed to its iron-chelating metabolite. However, recent experimental evidence suggested that the inhibition and/or depletion of topoisomerase IIβ (TOP2B) by dexrazoxane could be cardioprotective. Hence, we evaluated a series of dexrazoxane analogues and found that their cardioprotective activity strongly correlated with their interaction with TOP2B in cardiomyocytes, but was independent of their iron chelation ability. Very tight structure-activity relationships were demonstrated on stereoisomeric forms of 4,4′-(butane-2,3-diyl)bis(piperazine-2,6-dione). In contrast to its rac-form 12, meso-derivative 11 (ICRF-193) showed a favorable binding mode to topoisomerase II in silico, inhibited and depleted TOP2B in cardiomyocytes more efficiently than dexrazoxane, and showed the highest cardioprotective efficiency. Importantly, the observed ICRF-193 cardioprotection did not interfere with the antiproliferative activity of anthracycline. Hence, this study identifies ICRF-193 as the new lead compound in the development of efficient cardioprotective agents.

1-ACRYLOYLIMIDAZOLIDINE-2-ONE COMPOUND

To provide a compound that is expected to be applied to cell culture materials, temperature-responsive polymer materials and the like.SOLUTION: The present invention relates to a 1-acryloylimidazolidine-2-one compound represented by formula (1) (where R1a is a hydrogen atom, a C1 to 4 alkyl group, a benzyl group or an oxyalkyl group represented by formula (2). R2a is a hydrogen atom or a C1 to 4 alkyl group. R3a is a hydrogen atom or a methyl group).SELECTED DRAWING: None

Lipophilic polyamines useful for treating hypercholesterolemia

This invention relates to novel lipophilic polyamines of formula I, the method of using these compounds to treat hypercholesterolemia, and intermediates thereto.