442663-35-6

Upstream product

• 533-31-3 Sesamol 
• 100-39-0 benzyl bromide 
• 442663-43-6 (R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol 
• 1414948-46-1 (S)-5-(2-amino-3,3-dimethoxypropyl)-2-methoxy-3-methylphenol 
• 209624-66-8 3-hydroxy-4-methoxy-5-methylbenzaldehyde 
• 575444-12-1 3-(benzyloxy)-4-methoxy-5-methylbenzaldehyde 
• 1414948-51-8 (Z)-methyl 3-[3-(benzyloxy)-4-methoxy-5-methylphenyl]-2-[(tert-butoxycarbonyl)amino]acrylate 
• 1414948-54-1 (S)-methyl 3-[3-(benzyloxy)-4-methoxy-5-methylphenyl]-2-[(tert-butoxycarbonyl)amino]propanoate 
• 1414948-56-3 (S)-benzyl {3-[3-(benzyloxy)-4-methoxy-5-methylphenyl]-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate 
• 442663-44-7 4-methoxy-3-methoxymethoxy-5-methyl-benzaldehyde 
• 360778-72-9 (3R,5R)-3-(7-Hydroxy-6-methoxymethoxy-benzo[1,3]dioxol-4-yl)-6,6-dimethyl-5-phenyl-morpholin-2-one 
• 244126-23-6 toluene-4-sulfonic acid 5-bromo-2-hydroxy-3-methyl-phenyl ester 
• 244126-24-7 toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester 
• 244126-22-5 toluene-4-sulfonic acid 2-hydroxy-3-methyl-phenyl ester 

Downstream Products

• 442663-56-1 nitrile compound 
• 114899-77-3 ecteinascidin 743 
• 114899-80-8 (1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile 
• 442663-36-7 (1R,9S,10R,12R)-11-[(R)-2-Acetoxy-1-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-3-benzyloxy-10-cyano-12-formyl-4-methoxy-5-methyl-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2,4,6-triene-13-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 442663-58-3 alcohol compound 
• 442663-57-2 C₅₀H₅₈Cl₃N₃O₁₀Si 

Relevant academic research and scientific papers

Synthetic studies toward ecteinascidin 743 (trabectedin)

An alternative synthetic route to an intermediate in the synthesis of ecteinascidin 743 has been established by using a Pictet-Spengler reaction and a Friedel-Crafts type reaction.

PROCESS FOR TOTAL SYNTHESIS OF ECTEINASCIDINS AND INTERMEDIATES THEREFOR

An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R2 of N12 site is trichloroethoxicarbonyl (Troc) to which various substituents can be introduced by mild condition, further having 10 members ring structure which can be converted to a ring of other numbered members.

Total synthesis of ecteinascidin 743

The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation. Copyright