442899-64-1

Upstream product

• 442899-95-8 (3S,4R,5S,6S,7R,8R)-6-(tert-Butyl-dimethyl-silanyloxy)-8-(3,4-dimethoxy-benzyloxy)-3-methoxy-5,7-dimethyl-4-triethylsilanyloxy-nonane-1,2-diol 
• 214198-34-2 [3S,4R,5R,6S,7R,8R]-6-[(tert-butyldimethylsilyl)oxy]-8-[(3,4-dimethoxybenzyl)oxy]-5,7-dimethyl-3-methoxy-4-[(triethylsilyl)oxy]non-1-ene 
• 442899-66-3 (2R,3R,4S,5S,6R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(3,4-dimethoxy-benzyloxy)-2-methoxy-4,6-dimethyl-3-triethylsilanyloxy-octanal 
• 442899-67-4 4-[(1R,2R,3S,4S,5R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-1,2,4-trimethyl-5-triethylsilanyloxy-oct-7-ynyloxymethyl]-1,2-dimethoxy-benzene 

Downstream Products

• 442899-68-5 (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S,17S,18R,19R)-17-(tert-Butyl-dimethyl-silanyloxy)-19-(3,4-dimethoxy-benzyloxy)-7-hydroxy-2,14-dimethoxy-4,6,8,10,16,18-hexamethyl-15-triethylsilanyloxy-icosa-2,4,10,12-tetraenoic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of (-)-bafilomycin A1

A highly stereoselective total synthesis of (-)-bafilomycin A1, the naturally occurring enantiomer of this potent vacuolar ATPase inhibitor, is described. The synthesis features the highly stereoselective aldol reaction of methyl ketone 8b and