442899-66-3

Upstream product

• 443283-16-7 [3S,4R,5R,6R,7R,8R]-6-[(tert-butyldimethylsilyl)oxy]-8-[(3,4-dimethoxybenzyl)oxy]-5,7-dimethyl-3-methoxynon-1-en-4-ol 
• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 214198-34-2 [3S,4R,5R,6S,7R,8R]-6-[(tert-butyldimethylsilyl)oxy]-8-[(3,4-dimethoxybenzyl)oxy]-5,7-dimethyl-3-methoxy-4-[(triethylsilyl)oxy]non-1-ene 
• 442899-95-8 (3S,4R,5S,6S,7R,8R)-6-(tert-Butyl-dimethyl-silanyloxy)-8-(3,4-dimethoxy-benzyloxy)-3-methoxy-5,7-dimethyl-4-triethylsilanyloxy-nonane-1,2-diol 

Downstream Products

• 442899-67-4 4-[(1R,2R,3S,4S,5R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-1,2,4-trimethyl-5-triethylsilanyloxy-oct-7-ynyloxymethyl]-1,2-dimethoxy-benzene 
• 442899-64-1 C₃₃H₆₃BO₈Si₂ 
• 442899-68-5 (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S,17S,18R,19R)-17-(tert-Butyl-dimethyl-silanyloxy)-19-(3,4-dimethoxy-benzyloxy)-7-hydroxy-2,14-dimethoxy-4,6,8,10,16,18-hexamethyl-15-triethylsilanyloxy-icosa-2,4,10,12-tetraenoic acid methyl ester 
• 88899-55-2 bafilomycin A₁ 

Relevant academic research and scientific papers

Total synthesis of (-)-bafilomycin A1

A highly stereoselective total synthesis of (-)-bafilomycin A1, the naturally occurring enantiomer of this potent vacuolar ATPase inhibitor, is described. The synthesis features the highly stereoselective aldol reaction of methyl ketone 8b and