443-09-4

Usage

Preparation

Preparation by Fries rearrangement of p-fluorophenyl propionate (b.p.18–20 118–120°) with aluminium chloride at 150° for 1 h (80–81%) or at reflux for 30 min (57%) Also obtained by demethylation of 5-fluoro-2-methoxy-propiophenone (b.p.13 132°) with refluxing pyridinium chloride for 15 min (76%).

InChI:InChI=1/C9H9FO2/c1-2-8(11)7-5-6(10)3-4-9(7)12/h3-5,12H,2H2,1H3

Upstream product

• 653-64-5 1-(5-fluoro-2-methoxyphenyl)propan-1-one 
• 457-75-0 4-fluorophenyl propionate 
• 371-41-5 4-Fluorophenol 
• 79-03-8 propionyl chloride 
• 459-60-9 1-fluoro-4-methoxybenzene 

Downstream Products

• 342-16-5 1-(3-bromo-5-fluoro-2-hydroxy-phenyl)-propan-1-one 
• 389-39-9 2-bromo-1-(5-fluoro-2-hydroxy-phenyl)-propan-1-one 
• 846-69-5 4-fluoro-2-(5-methyl-2-pyridin-2-ylamino-thiazol-4-yl)-phenol 
• 16113-35-2 1-(4-Fluor-benzoylhydrazono)-1-(5-fluor-2-hydroxy-phenyl)-propan 
• 852-06-2 2-[2-(2,5-dichloro-anilino)-5-methyl-thiazol-4-yl]-4-fluoro-phenol 
• 16108-83-1 1-(4-Acetamino-benzolsulfonylhydrazono)-1-(5-fluor-2-hydroxy-phenyl)-propan 
• 1391466-69-5 (1-(4-[(7-chloro-3-methylbenzofuran-2-carbonyl)amino]benzyl)-3,5-dimethyl-1H-pyrazol-4-yl)acetic acid 
• 2839-49-8 2-fluoro-9H-xanthen-9-one 
• 653-64-5 1-(5-fluoro-2-methoxyphenyl)propan-1-one 
• 398-88-9 4-fluoro-2-propylphenol 
• 846-68-4 2-(2-anilino-5-methyl-thiazol-4-yl)-4-fluoro-phenol 
• 1766-39-8 4-fluoro-2-[2-(3-fluoro-anilino)-5-methyl-thiazol-4-yl]-phenol 
• 3900-32-1 2-[2-(3-chloro-anilino)-5-methyl-thiazol-4-yl]-4-fluoro-phenol 
• 2803-64-7 4-fluoro-2-[5-methyl-2-(4-methyl-anilino)-thiazol-4-yl]-phenol 

Relevant academic research and scientific papers

ANTI-INFECTIVE AGENTS

The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES

The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.